本發(fā)明涉及地中海貧血癥篩查診斷
技術領域：
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背景技術：
：地中海貧血又稱海洋性貧血，多見于地中海、東南亞等地，是一組對人類健康具有嚴重威脅的致死、致殘的遺傳性血液病；在1925年由意大利Cooley醫(yī)生和Lee醫(yī)生首次報道；有數據表明，我國重型和中間型地貧患者在30萬人左右，“地貧”基因攜帶者超過3000萬人，涉及近3000萬家庭1億人口，主要集中在長江以南的云南、四川、海南、貴州、福建、廣西、廣東等市、省份或自治區(qū)，尤以兩廣地區(qū)最為嚴重，廣東“地貧”基因攜帶者超過10％，廣西“地貧”基因攜帶者超過20％，由于基因攜帶率高和人口基數大，預防地中海貧血癥已經成為我國南方人口出生缺陷的公共衛(wèi)生戰(zhàn)略需求。地中海貧血癥的病因是由于血紅球蛋白基因缺陷而導致血紅蛋白中的一種或幾種血紅球蛋白肽鏈的合成減少或者不能合成，導致血紅球蛋白的組成成分或者比例發(fā)生改變。血紅球蛋白由兩類亞基組成，一類是α亞基，一類是β亞基；α類亞基簇位于16號染色體，簇的順序為5'-zeta(ζ)-pseudozeta–mu(μ)-pseudoalpha-1-alpha-2-alpha-1-theta-3'，其中α1和α2的編碼序列完全相同，不同的是5’UTR區(qū)、3’UTR區(qū)和部分內含子區(qū)域；β類亞基簇位于11號染色體，簇的順序為5'–epsilon(ε)–gamma-G–gamma-A–delta(δ)–beta(β)-3'，如圖1所示。組成血紅球蛋白的肽鏈有4種，分別是α、β、γ和δ鏈，這些肽鏈由相應的基因編碼，這些基因的缺失或者點突變可造成不同的肽鏈的合成障礙，致使血紅蛋白的組分改變，因此通常地中海貧血可以分為α、β、δβ和δ等四種類型，其中又以β和α地中海貧血較為常見。α地中海貧血簡稱α地貧，α血紅球蛋白基因簇位于16p13.3，每條染色體上各有2個α血紅球蛋白基因，一對染色體共有4個α血紅球蛋白；大多數α地貧是由于α血紅球蛋白基因的缺失照成的，少數是由基因點突變造成的。β地中海貧血簡稱β地貧，其基因簇位于11p15.5，β地貧的發(fā)生主要是由于基因的點突變，少數為基因缺失，迄今為止全世界已經發(fā)現的點突變有1000種以上，根據公開的資料，如圖2是地貧點突變的統(tǒng)計數據，可以看到β亞基上的突變占到50％以上。各國的突變熱點也有所不同，下面列舉了中國、日本、俄羅斯和韓國的β亞基的突變熱點和突變頻率的數據：其中，中國的β亞基的突變熱點和突變頻率統(tǒng)計如圖3所示。其中，日本的β亞基的突變熱點和突變頻率統(tǒng)計如圖4所示。其中，俄羅斯的β亞基的突變熱點和突變頻率統(tǒng)計如圖5所示。其中，韓國的β亞基的突變熱點和突變頻率突變頻率統(tǒng)計如圖6所示?？梢钥吹剑鲊闹饕蛔儫狳c和頻率不盡相同，例如，韓國的CD41/42(-TTCTor-CTTT)熱點的頻率是5.6％，而中國該位點的頻率是42.3％，對于CD89/90–GT熱點而言，韓國的頻率是38.9％，而中國卻沒有統(tǒng)計到該位點，但實際上，中韓兩國在漫長的歷史中，并不是嚴格的地域隔絕，中國的朝鮮族與韓國有著共同的血緣背景，因此可見，由于統(tǒng)計范圍的關系，這些公開的數據并不能準確的反應國內β亞基突變位點的情況，國內以β亞基熱點作為檢測對象的試劑盒并不能適用于所有情況，可想而知，將會有較大比例的假陰性的情況出現；并且，國內市面上的檢測地中海貧血癥的檢測試劑盒是將β亞基和α亞基分開檢測，并且技術平臺也不一樣，例如，檢測β亞基點突變的是qPCR方法，檢測α亞基基因缺失的是gap-PCR或者MLPA(multiplexligation-dependentprobeamplification)，本發(fā)明的主要優(yōu)勢在于：1)可同時檢測α基因簇和β基因簇上99％的已知點突變，數量約在3000個以上；2)除了可以檢測點突變這種類型之外，還可以檢測小片段的插入、小片段和大片段的缺失以及拷貝數變化等多種類型；3)在檢測已知類型的突變、插入、缺失、拷貝數變化的同時，還能識別未知的新發(fā)的基因變異；4)與傳統(tǒng)方法比較，有較大的成本優(yōu)勢；技術實現要素：本發(fā)明提供一種基于二代高通量測序技術的地中海貧血癥的基因檢測試劑盒，可以減少目前檢測方法的假陰性率，提高檢出率，可以實現自動化，使地中海貧血癥的篩查診斷更加全面和準確。本發(fā)明所采取的技術方案是：一種基于二代高通量測序技術的地中海貧血癥的基因檢測試劑盒，其中包括：1)基因組DNA提取試劑；2)含有外切酶的片段化試劑；3)片段修復與連接試劑；4)PCR擴增試劑；5)PCR產物純化試劑；6)捕獲探針及其雜交捕獲試劑；7)雜交洗脫試劑；8)陰性質控樣本；9)陽性質控樣本；其中捕獲探針所捕獲的范圍如下所述，其核苷酸序列見序列表：1)hg19，chr16:189,137-232,194；2)hg19，chr11：5,237,140-5,318,776；3)KLF1基因的全部外顯子區(qū)域以及5’UTR和3’UTR區(qū)域；4)以及156個SNP位點本發(fā)明還提供了地中海貧血癥的基因檢測試劑盒在遺傳病篩查和診斷中的應用，包括下述步驟：1)用權利要求1所述的1)基因組DNA提取試劑從受測試者唾液或者血液中提取基因組DNA；2)用權利要求1所述的2)含有外切酶的片段化試劑將基因組DNA進行片段化處理；3)用權利要求1所述的3)片段修復與連接試劑將DNA片段的末端進行修復；4)用權利要求1所述的3)片段修復與連接試劑將修復后的DNA片段與人工接頭進行連接；5)用權利要求1所述的4)PCR擴增試劑以連接后的DNA片段作為模板進行PCR擴增；6)用權利要求1所述的5)PCR產物純化試劑對PCR產物進行純化；7)用權利要求1所述的6)捕獲探針機器雜交捕獲試劑與PCR產物進行雜交；8)用權利要求1所述的7)雜交洗脫試劑對雜交后的PCR產物進行純化和洗脫；9)用權利要求1所述的4)PCR擴增試劑以洗脫后的PCR產物作為模板進行PCR擴增；10)用權利要求1所述的5)PCR產物純化試劑對PCR產物進行純化；11)對純化后的PCR產物進行二代高通量測序；12)對測序結果進行分析獲得受測試者的地中海貧血癥相關基因的信息；附圖說明圖1是α類亞基簇和β類亞基簇。圖2是地貧點突變的統(tǒng)計數據圖。圖3是中國的β亞基的突變熱點和突變頻率統(tǒng)計圖。圖4是日本的β亞基的突變熱點和突變頻率統(tǒng)計圖。圖5是俄羅斯的β亞基的突變熱點和突變頻率統(tǒng)計圖。圖6是韓國的β亞基的突變熱點和突變頻率突變頻率統(tǒng)計圖。圖7是典型的DNA提取結果。圖8是Swift文庫(E1～E7，E15～E21)和VAHTS文庫結果圖(E8～E14，E22～E28)。具體實施方式本發(fā)明一種基于二代高通量測序技術的地中海貧血癥的基因檢測試劑盒及其在遺傳病篩查中的應用，屬于地中海貧血癥基因診斷
技術領域：
，是一種靶向性測序技術，包括：1)基因組DNA提取試劑；2)含有外切酶的片段化試劑；3)PCR產物純化試劑；4)片段修復與連接試劑；5)捕獲探針及其雜交捕獲試劑；6)雜交洗脫試劑；7)PCR擴增試劑；其應用包括以下步驟：1)從受測試者唾液或者血液中提取基因組DNA；2)用外切酶將基因組DNA進行片段化處理；3)用生物酶將DNA片段的末端進行修復；4)用連接酶將修復后的DNA片段與人工接頭進行連接；5)以連接后的DNA片段作為模板進行PCR擴增；6)對PCR產物進行純化；7)用捕獲探針與PCR產物進行雜交；8)對雜交后的DNA片段進行純化和洗脫；9)以洗脫后的DNA片段作為模板進行PCR擴增；10)對PCR產物進行純化；11)對純化后的PCR產物進行二代高通量測序；12)對測序結果進行分析獲得受測試者的地中海貧血癥相關基因的信息。本發(fā)明的試劑盒以及操作步驟能適用于現有的自動化工作平臺，提高反應通量，縮短篩查診斷時間，使地中海貧血癥的基因檢測更為快捷可靠。本發(fā)明選擇HBA家族所在基因簇和HBB家族所在基因簇作為檢測對象，囊括了更多目前技術方法無法顧及的檢測位點，可直接對受測試者的突變攜帶進行確診，顯著降低突變的漏診率，測試的準確性和全面性超過其他常規(guī)測試方法。本發(fā)明填補了地中海貧血癥的二代高通量測序診斷
技術領域：
的空白，極大提高了地中海貧血癥的基因缺陷的檢出率，對降低病患兒的出生率、提高我國人口素質、減輕我國醫(yī)療保健體系的負擔等方面具有重要意義。實施例11.樣本DNA提取我們比較了兩款商品化的外周血DNA提取試劑盒，分別是天根生物DP304TIANampGenomicDNAKit和Qiagen56504QIAampDNAInvestigatorKit，按照廠生產廠家建議的操作流程，最終我們選擇了天根生物DP304，典型的DNA提取結果如圖7所示。2.實施例方案設計為了證明本方案流程的可靠性，我們用5個樣本做了30次不同重復，方案設計如下表，具體而言，我們由兩位操作人員，在3個不同的時間節(jié)點里分別對相同的5個樣本進行重復實驗；3.DNA片段化1)二代測序文庫要求將樣本基因組DNA片段化，在比較了超聲和酶切兩種方式之后，本發(fā)明采用NEB公司的NEBNextdsDNAFragmentase對樣本基因組DNA進行片段化處理，并比較了不同酶切時間的片段化效果，最終采用20分鐘的酶切時間；具體實施步驟如下：2)在0.2mLPCR管中按比例加入下列組分，總體積10uL，稍微渦旋3sec，無熱蓋，37℃孵育20分鐘；3)加入合適體積的Beads到PCR管中后，稍微渦旋混勻，稍微離心，在室溫下放置5分鐘；4)在磁力架上放置5分鐘；5)在磁力架上，移除管中上清，留下5μL溶液，禁止觸動磁珠沉淀；6)在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；7)重復：在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；8)低速離心30sec，在磁力架上小心移除余液，置于室溫下風干(避免磁珠沉淀開裂)；9)用12μLTE重懸浮磁珠，吹吸5-6次，室溫靜置1分鐘，置于磁力架上5分鐘，將11μL上清移入新的PCR管中4℃?zhèn)溆?，也可以?20℃中保存一周；4.文庫構建我們選擇了Illumina公司的Truseq建庫試劑盒、Swift公司的Accel建庫試劑盒和VAHTS公司的Nano建庫試劑盒，從操作步驟、試劑價格、建庫效果等多個方面進行比較，最終確認VAHTS公司的Nano建庫試劑盒性價比最高，并在生產廠家提供的操作流程的基礎做了適合本發(fā)明方案的改動，具體實施步驟如下：1)將EndPrepMix解凍后顛倒混勻，組分按照下表的比例加入PCR管中，移液器輕輕吹吸5-6次，稍微離心后，放入PCR儀中，30℃反應30分鐘，Holdat4℃；2)加入合適體積的室溫的混勻的Beads，稍微渦旋混勻，稍微離心，在室溫下放置5分鐘；3)在磁力架上放置5分鐘；4)在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；5)重復：在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；6)低速離心30sec，在磁力架上小心移除余液，置于室溫下風干10分鐘左右(避免磁珠沉淀開裂)；7)按照下表體積加入的6.3μLddH2O，室溫振蕩或者吹吸混勻磁珠，于室溫放置2分鐘，磁力架上靜止5分鐘；8)吸取5.8μL上清液到新的PCR管中，禁止觸動磁珠沉淀；9)將dA-TailingMix解凍后顛倒混勻，組分按照下表比例加入到上一步含有純化產物的PCR管中，吹吸5-6次，放入PCR儀中，37℃反應30分鐘，70℃反應5分鐘，4℃反應5分鐘，Holdat4℃；試劑名稱純化后的末端修復產物5.8μLdA-TailingMix4.2μLTotal10μL10)將StopLigationMix解凍后顛倒混勻，置于4℃?zhèn)溆茫?1)末端dA-Tailing反應之后，按照以下配比立即進行Ligation步驟，混合物吹吸5-6次，放入PCR儀中，30℃反應10分鐘，Holdat4℃；試劑名稱dA-Tailing產物10μLLigationMix1μLDNAAdapterX1μLTotal12μLStopLigationMix2μLDNAAdapterX：VAHTSN801，N802，N803，N804，N805，N806中的任一種adapter12)加入StopLigationMix之后，加入14μL混均的Beads13)用移液器吹吸10次，充分混均，在室溫下放置5分鐘；14)在磁力架上放置5分鐘；15)在磁力架上，移除管中上清，禁止觸動磁珠沉淀；16)在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；17)重復：在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；18)低速離心30sec，在磁力架上小心移除余液，置于室溫下風干(避免磁珠沉淀開裂)；19)加入11.5μLddH2O，吹吸均勻后，室溫放置2分鐘，短暫離心后置于磁力架上靜置5分鐘，小心吸取11μL上清至新PCR管中，禁止觸動磁珠沉淀；20)P7Primer:CAAGCAGAAGACGGCATACGA21)TaqPlusDNAPolymerase，ET105，天根生物22)將PCR組分按照下表比例進行配置和反應23)PCR循環(huán)設置如下：24)加2倍PCR反應體積的室溫的混勻的Beads到PCR管中，稍微渦旋混勻，稍微離心，在室溫下放置5分鐘；25)在磁力架上放置5分鐘；26)在磁力架上，移除管中上清，留下5μL溶液，禁止觸動磁珠沉淀；27)在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；28)重復：在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；29)低速離心30sec，在磁力架上小心移除余液，置于室溫下風干(避免磁珠沉淀開裂)；30)用20μLTE溶液重懸浮磁珠，吹吸5-6次，室溫靜置1分鐘，置于磁力架上5分鐘，將上清移入新的PCR管中4℃?zhèn)溆?，長期保存需要放在-20℃中；31)將合成的探針在室溫下融解，待用；如果是干粉，將探針終濃度用TE溶液調整為0.75pmol/μL；32)將UniversalBlockingOligos用TE調整到1rxn/μL；試劑名稱試劑數量PCR產物500ngCot-1DNA5μgTS-p5BlockingOligo1μLTS-p7,6ntblockingOligoX＝________μLTS-p7,8ntblockingOligoY＝________μLX＝ReagentY2(I1～I12)的數量/文庫混合物中index的總數Y＝ReagentY2(I13～I27)的數量/文庫混合物中index的總數且，X+Y＝133)混均上述物質，然后用HeatingBlocker進行85℃烘干，大約需要1個小時；34)將下列試劑按照表中比例在1.5mL管中配置合適用量的mix，在每個含有已烘干的文庫DNA的0.2mLPCR管中加入13μL；2×HybridizationBuffer8.5μLhybridizationBufferEnhancer2.7μLNuclease-FreeWater1.8μL35)在PCR儀中95℃變性10分鐘；36)將PCR管移出PCR儀器，立即加入4μL0.75pmol/μL合成探針庫，稍微渦旋震蕩后離心；65℃雜交過夜；37)將雜交后樣本溶液轉移到含有100μL已活化的鏈霉親和素磁珠的PCR管中，吹吸混勻10次；38)震蕩混勻之后，將混合物移入HeatingBlocker中，需要在65℃孵育45分鐘；39)加入65℃預熱的分裝的100μL1×WashBufferI；40)稍微渦旋震蕩和稍微離心后將混合物轉入新的1.5mL管中；41)將1.5mL管放置在磁力架上，直至上清澄清；42)移除上清，加入200μL65℃預熱的1×StringentWashBuffer，緩慢的吹吸10次，禁止產生氣泡；43)將1.5mL管置于65℃金屬浴中5分鐘；44)將1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；45)再次加入200μL65℃預熱的1×StringentWashBuffer，緩慢的吹吸10次，禁止產生氣泡；46)再將1.5mL管置于65℃金屬浴中5分鐘；47)再將1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；48)加入200μL室溫的1×WashBufferI，漩渦振蕩2分鐘；49)將1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；50)加入200μL室溫的1×WashBufferII，漩渦振蕩1分鐘；51)將1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；52)加入200μL室溫的1×WashBufferIII，漩渦振蕩30sec；53)將1.5mL管放置在磁力架上，直至上清澄清，小心移除所有溶液；54)將1.5mL管從磁力架上拿出來，加入20μL去離子水，上下吹吸10次重新懸浮所有磁珠；55)將PCR組分按照下表比例進行配置和反應：56)PCR循環(huán)設置如下：57)加75μL室溫的混勻的Beads到PCR管中，稍微渦旋混勻，稍微離心，在室溫下放置5分鐘；58)在磁力架上放置5分鐘；59)在磁力架上，移除120μL的管中上清，留下5μL溶液，禁止觸動磁珠沉淀；60)在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；61)重復：在磁力架上，加入160μL新鮮配置的80％乙醇，靜置30sec，移除160μL洗滌液；62)低速離心30sec，在磁力架上小心移除余液，置于室溫下風干(避免磁珠沉淀開裂)；63)用20μLLow-TE重懸浮磁珠，吹吸5-6次，室溫靜置1分鐘，置于磁力架上5分鐘，將上清移入新的PCR管中4℃?zhèn)溆?，也可以?20℃中保存一周；典型的產物結果如圖8所示，64)將PCR純化產物送由測序供應商進行測序。5.數據分析1)數據比對分析如下表所示：可以看到，一共30個測序文庫，平均有8.92Mreads的數據，由于數據量與測序文庫上樣的操作差異有關，可能有多有少，不具備比較和統(tǒng)計的意義，但可以看到Q30＝91.53％±1.34％，Mappingrate＝97.00％±3.81％，Ontargetrate＝58.08％±3.07％，符合預期，說明我們測序的質量是很好的；；2)數據覆蓋率分析結果如下表所示：SampleMeanDepth1×4×10×20×50×100×250×500×1000×92-L2552200.99860.99750.9970.99530.99410.98910.97420.95120.900192-L2655130.99850.99680.99640.99390.98850.97660.95870.93150.886992-L276298110.99950.99910.99810.99650.98230.95970.911992-L2870190.99740.99710.99670.99610.99570.99510.98760.97210.934792-L2977640.99750.99750.9970.99670.99590.99480.98120.96290.929798-L6155850.99870.99740.99690.99570.99480.99420.99290.98520.966398-L6260590.99970.99790.99720.9970.99540.99450.99310.98720.970398-L6347410.99970.99970.99970.99920.99890.99790.99460.98350.953998-L6455510.99880.99750.99750.99710.99550.99490.99450.98860.968698-L6556310.99860.99730.99710.99690.99650.99520.99370.98670.965800-L7348310.99610.99460.9940.99320.99260.99220.98860.97180.944700-L7453610.99750.99660.9950.99390.99320.99280.99180.98610.971300-L7557740.99930.99880.99840.99750.9960.99570.99470.99190.976300-L7652810.99840.99670.99650.99590.99430.99340.99230.98870.973600-L7759950.99650.99580.99560.99550.99330.99270.99190.98950.976594-L3770650.99680.99660.99580.99440.99310.99060.98270.96450.927694-L3872160.99860.99720.99670.99570.99390.99280.98190.96520.925494-L3977010.99980.99980.99920.9990.99740.9960.98510.96940.93694-L4064230.99680.99670.99650.99620.99430.99180.98630.96990.936494-L4172170.99750.99750.99730.99720.99560.99220.98120.96150.931196-L4955980.99870.99740.99660.99650.9960.99520.99080.97920.95296-L5050230.99760.99710.99690.99610.99530.9950.99370.98460.958196-L5148760.99980.99960.99850.99810.9980.99780.99490.98720.952496-L5247120.99910.99730.99680.99590.99520.9950.99250.98450.950596-L5348290.99870.99750.99720.99720.99610.99530.99340.98270.952102-L8554500.99590.99490.99450.99440.99440.99380.99290.99080.981402-L8656700.9980.99610.99570.99560.99530.99460.99310.99140.985302-L87525210.99960.99930.99860.9980.99740.99640.99440.989602-L8856980.99780.99690.99660.99580.99520.99490.99350.99220.988202-L8973000.99740.9970.99680.99620.99550.99490.99330.99240.9898Average5888.430.99830.99740.99700.99630.99520.98880.98880.97820.9529Std918.780.00120.00130.00140.00150.00200.00380.00790.01480.0268對于遺傳性分析而言，高質量的50×數據足以獲得可靠的結果，數據分析顯示我們在50×時，能覆蓋到目標區(qū)域中99.52％±0.02％的堿基，完全符合預期。<110>上海閱爾基因技術有限公司(該專利申請的所有申請人的姓名或名稱）<120>發(fā)明名稱<160>879<210>1<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>1gagcagacaactggtggatctgtacaaggtgctggagagcaggggctccgacccaaagcc60cgaaaacccagcctgtccctggacggtgctcccagcaggtgaccttcccacccatgatgg120<210>2<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>2acatatattatattaaaaatatataattgtatttttcaacctacaaaattatctcgagtt60caatatggcaagtcatttatgagaaccaactattgtgttctttacctgaaattgaaaatg120<210>3<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>3cacagtggaaggcttctctgtggacagagactgaagggtgtggaggtatcgaagctgaac60ggcagcaggggtgcctgacagaatctcagctgccatcctcagggactcagaagcagcctt120<210>4<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>4gttagtgaaacctgaattcattcttttttttttaggccttccttgtaaatctccacctga60gatttctcatggtgttgtagctcacatgtcagacagttatcagtatggagaagaagttac120<210>5<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>5aattttaaactaaggggaaccactaatggcatgtatcctttcctttcagatgataattta60ttgtgatgttagagaattcaaggttgcagtaaatggcgtacacagcctggagtacaaaca120<210>6<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>6ggtggcggctgtttcatctttatcatcaggtcttacattcacatcttttcgaccgtgctc60gggtttccaagaggagcagacagaacaaaggccttttccacctgcatccctcacatcctg120<210>7<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>7tgccagaggaaaagctgttcagtatccaagatgcatcaggtccaatcccaggggttccta60gttctccttctgtgcctgctgtaacctcttggccacagcagtgatcagtgctgccccttt120<210>8<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>8aaacagaggatactactggagtggaggagtggaagcagcccagcaggcccactggtagcc60gtgagtgtgaggatagcttatcggtagcggcaggccaaagcattgacattcttgaccaca120<210>9<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>9cctggccctccttgagagtggcatggaggaggaagaagactcgcccaggcccatgggagt60cggatggtggccgcacttgtggggccctgaccccataggcttcttcagcacgccctggcc120<210>10<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>10gcccgttccttcttccccatgccccgctcatgggtcagagggccggtgctggggtccaga60tggtgtcaacagggatggtccctgtcctccccagagacagaagcctgtggcccacggagg120<210>11<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>11tcaatatgactggcagccctgcacctcccattgtgtcctatccttctcttacttgctatg60ccaactcactaccccaacatattgtgattgtttcattttttttttagagacttcgtcctt120<210>12<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>12tttgtatgttattccaggggggaagaggaatccctgttgggcagcagcagctgctgccag60agtccgctggtcatgtggaaaaattgggatcatgagcggaggcatgtgaccctgaacctg120<210>13<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>13ccttagtctacaacaggccttttctgaacttagacgtgcccaaatgacagaaggacccaa60cacagcacctccaaactttagtcatacaggaccaacatttccagtagtacctcctttctt120<210>14<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>14ctatactgagtaatttaaaactctcacccttctttcatcttatctgccttagatttctca60cgtacatccaacttctcttgctctcccataaaagcctgcttgcccgttttcctgtcccct120<210>15<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>15ctagctccaggggcgatcccattcttctccccactttcctaaatgagcagcgttcaaaca60cttttgtagaagaaacccttgccctaaatctgatgctaaaccccagtaggtaaaaaacaa120<210>16<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>16tagtcccccatttgtcttcactctgcaaatgatttggccagtaggtgaggggggataaat60ctcaggctgaccagtgttggcccattcattgtagacctcactgataaggattacatctgt120<210>17<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>17ctcaggctggtgacggtagctgtgaattatgatcaaatgagctggatcaaagtccaggat60agaagtcacagagaactgcgaaggactaatactgaagactaacattaaatgagcactga119<210>18<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>18cccagtgtttggggctctatcagcaagtaggtctatacatactggaagcaggtgacggga60ctgttaagggaaaggggggctgatgaaagatgagaaataataaatggaagaaaaaaaagt120<210>19<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>19tatgagtcatgtttgggtttttatttaaaagattttgatttcattgaacttagagcaacc60gagaacaagaactgggtttcgtggcaagggaaaatcaagtcagatgtatacatttgccac120<210>20<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>20gttctcttaaaacagatgaaacaatataggagagtggatgctggcagaaaaaggcgtagc60attggaaggagtgtttagacagaatggttcctgctcctcttgctccaggaaaagggcctg120<210>21<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>21cccacagggcagaaccacttcctctcatgacaggaaaccaatgaatggggcaggccacac60gaactgggagaattacttcattccctcatgacacccttccatttactcttccttttactt120<210>22<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>22gaccagccctatgagagaagtggacttcgacaccttttttacgtcatccaagatggtcac60actggactccatatactttcagcctggctcccgggtacagtgcgcagctcgtgctgtgaa120<210>23<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>23ggccagccagggtgggcgagacaccataagtggcaaagacatgagaaacgggctcacctt60gggtccccggggtccatcaggcccttgatagccatccaggcctcggcttccctgcaagaa120<210>24<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>24tgatggatgtcgcaggatgagtgctctggcagaggcaagccccacaattccgccaccaac60gatgactatatcaaatgagcttcaaaagaaagtcatctttaaagtaattcatatttacag120<210>25<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>25gctctaacagatacagataacacattagagttcaaaagtgggaatgcagtttggctagtg60caagtggcagatttcctctgccttcatacttgattcatttccaggcaggcatctggaagg120<210>26<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>26cccagtgggatgaccctcactgagagtagcagcaagggaacctgaggttttgtcacactt60tgttcttccagggttgctatcagcactggatcttgttgaagtcaatcctcagttggccac120<210>27<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>27ccaaagacagcaagttcaaaatgcccaagttcaagatgctgtcgtttggggtgtctgccc60ttggcaagtccatcgaggcctcagcggatgtgtctgcgttgaaggtggaggccgacgtga120<210>28<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>28cgtcctacagataccacaacctggatcaggtccaagcaaaacgtccagagtgctacaaaa60tgttgcgttctcagtccaaaaagaagtggaaaagaatctgaagtcatgcttggacaatgt120<210>29<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>29tggcgggcgcctgtagtcccagctactggggaggctgaggcaggagaatggcctgaaggc60gggaggcggagcttggcgggaggaggagaatggcgggaaggcgggagttgcagtgagccc120<210>30<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>30ggatgcaggtgagacctggaccagctgctcagaagagttgcaagtggttctctcgagggc60cgagtgtggttctcaaccggaaactcagtccctgacaacccgaccactcccgggaaacta120<210>31<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>31gggaccggggacctgggacctggcaacaggctgctgccctcaagccacactggccatgac60ggctcttctggggcgcagaggtgtcagctgtcctggtagtggtatgagatcctgctctgc120<210>32<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>32acaaggaaggagttgttttcaccaggagcttctaaaactccctgatggagaagccagggc60gccacccaactccaccgctcaccacaaagcgcccttgccttaagtaagagccaacagcac120<210>33<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>33gtggcctcctgagcgattcacattcccagcctatattcacagatgttaggtcctgcagga60cagggccaccaggctattcagccacaccataaccctagctttaattaaaatagcaactgg120<210>34<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>34tcagccagggtaacatggcaaaatcccatttccacaaaaaaatacaaaaactattcaggc60gtgggggcgggtgcctatagtcccagctactcgggaggccgagatggaaggatcacctga120<210>35<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>35agggcacccaggcatttccagagccatctctgttactattcaggcagccactcccaagaa60cagagcatgggggctgacagcccacatgtctatggatgggccctggaggggactcaggaa120<210>36<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>36acatctgcccaagccaagggtggaggcatgcagctgtgggggtctgtgaaaacacttgag60ggagcagataactgggccaaccatgactcagtgcttctggaggccaacaggactgctgag120<210>37<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>37aactgggccaaccatgactcagtgcttctggaggccaacaggactgctgagtcatcctgt60gggggtggaggtgggacaagggaaaggggtgaatggtactgctgattacaacctctggtg120<210>38<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>38tctgcacgcatccctgtgcactgtccccttgccctccacgcggctctttgggtgaagggc60cgctctgtgggtgaagggcctgggtcctgggagttgaaggtgcagcacagcaaacctgag120<210>39<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>39gaaaagaaaatggatattgtccagtgtctctaagacttgaaaccaaggtcagaaaagatg60tagtgttccctgggtattaggggccatggtgctcatgtttaaatgtaccgtgtgtcccca120<210>40<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>40cctggccgtgttgggagttgtctgccctgtgcatagatgcagatctatccacaggaaaag60ggaacgtcgcgtgaggtttttcatcgcacgaattgttctgtggcgcccttttcccatagt120<210>41<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>41tcaaaaaaaaaaaaaaaagttacgtgaacatctgaagttgtctttgccacccccagttct60agcaagcacagggatcacccctggccgtgttgggagttgtctgccctgtgcatagatgca120<210>42<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>42tcgcgagcccggagcgtggcacgtgggttggtaactgtggcgctgctccgcgtccaccac60cacccctgtcctcctcaggccccctccgcctccacccctgccctcctcaggccccctccg120<210>43<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>43taacacagtgcaaccccgtctctactaaaaaaaacacacaaaaaattggccgggcgtgat60agcgggcgcctgtagtcccagctattcgggaggctgaggcaggagaatggcgtgaaccag120<210>44<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>44ccacccgactgtccctgcacggtagagaggcaggagcgcctctccctgcacggatggtgc60cccggaggctaccaggggcggccgaggacactgatgctgcatcccaggaggacctgtcct120<210>45<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>45ctttactgacattttctcctttactcccacaaatttaggtttaaaatatttccatcagtt60aatctccaatggctaggtccttccaatgaggtctcctgaaaacatgtggcctggatactc120<210>46<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>46gccatccttaaacatcaccttaaaggtgtccatccatgtgtgccctgcttcagacacagg60atgagcatgggtgaaagtttagagctggagataccagtcacccagctctgcatactttcc120<210>47<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>47gtatacagggggaggctggctaatttcccaccatcctatcctgaggtcctagtatgcggt60aaggggggctccatcagtgtgaagggagacaattcaaagtagtggaaatacgtccaacct120<210>48<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>48cctgctccatttccagtctgaaaataagtggaagagctaaagatccacacttaacaatga60aggcatccttactgccagcattgagactgtaaccataaacgagtcctatgttccaatgaa120<210>49<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>49tcaagaccagccttcccaatacagtgaagccccatctctactaaaaacataaaaattagc60tgggcgtggtagcatgcacctgtagttccagctactcaggagactgaggcagaagaatcg120<210>50<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>50aataagttacgataaacatcttttctctgcattcattttcacatatccttaagacacatt60cccaacagtggaattctggaaaaaaatgtttaaaacaccaacagtaggccaggtgcaatg120<210>51<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>51gcctcaaaaaaatgtgtattccactccagttgtaaatatctttagatcagcttttcattg60catttgatggggagaacacagaaatgatagtctgcaaatcatccaggtgaattgttatac120<210>52<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>52aggcatatgtaagcagttattttatgtgataatagaattatagcatgcacttatgtgtgc60atagtctggcatatacttctattatattaaacctctattatttatttatttatttttga119<210>53<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>53gttttgaaacaagatgctaagcatggcagagtttgaagttgcatttcatcttaaggacca60agggaggtaactttaaggttgccagtggtggatccagctccattaggctacgttgtcta119<210>54<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>54actccatctcaaaaaaaaaacaggccgggagtggtctattttgacactccacctcaaaaa60aattaattaattaaaaaataaaatttaaattttaaaaaatcatttcacaaatgataattt120<210>55<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>55actccatctcaaaaaaaaaacaggccgggagtggtctattttgacactccacctcaaaaa60aattaattaattaaaaaataaaatttaaattttaaaaaatcatttcacaaatgataattt120<210>56<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>56cgcctccgaggttcacaccattctcctgcctcagcctcccaagtagctgggactataggc60gcccgtcaccacgcctggctaattttcttgtatttttaatagagacggggtttcacagtg120<210>57<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>57catgagccactgtgcccggctgacaagttttaaataatgttttaaggcatgactttgctt60ccaattggccatttgaacaaagcaattaaatcatctgaattacgcacctaccaaactgcc120<210>58<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>58catgactttgcttccaattggccatttgaacaaagcaattaaatcatctgaattacgcac60ctaccaaactgccacagttactagaaatcagacaactgccaggcacagtggcccatgct119<210>59<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>59ctcagttcaccgcaaactcttgcctcccaggttgaagcaactctcctgcctcagcctccc60gagtagctatgattacaagcacgcgccaccaagtccagctaattttggatttttagtaga120<210>60<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>60tgagagtgtttttttatggtggaagaatgtggatgagaagcctcacgggggtcggagagg60cgtgtcctctctcgggacgctgtctgcaagcttgtccgtccggcaccccgggaaagctcc120<210>61<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>61acactaatttgtgggggagttgcaggaaatctgccttggaattcaggagaaaggcttact60ccatggtattttctggacagactacaaaacttattctgtgtaatagttgcctatcagctg120<210>62<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>62agcgattctcctgcctcagcctcctgagtagctgggattactgatgcacatcaccacgcc60tggttaattttttgtatttttagtagagatggagtttcaccatgttggccaaattggtct120<210>63<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>63aaaaacattggtatcttcttgctgttgatgagcaaatctttggacctgtctcatggtgtc60tttatttgcaaactggttgaatcatgaactgcctggctttggctgccttgccgttgtggc120<210>64<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>64gtgagccaccgcgcctggccttattaatgatttttaaatcagtttctcacaaactctttt60gatcttagatcagtctgtgtttttcataaatgcctcaacggctggctcggttttagaaac120<210>65<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>65gggggcagaactgtgtctgcgagtctagaagtggcctttaaacagtgaatcaatcccaag60aggctgccagttctatgtccaaggttttcccggagttttagggagcgatagaccagcctt120<210>66<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>66cctgtgaggcactggggctgccctgcctgcctcatgtgccccgtgcagtgtggaggcacc60aaccatcgtggcagactctctgatgtcagcgtgtctttcctcaaaaccaagagcctgtgg120<210>67<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>67gacaggtgcccactacatcctctttccctgcggtacgttgtttctgccacatccctggcc60agcctcactcgtggagcatgactgccctgcggctcctcaggtcctgcttctgctctcgag120<210>68<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>68ctggacgggcaggagctgacgcctcgctggacacccaaggcagcccatgtcctgaggtac60agggtttccccaaggaccgcgcaggtgctgcaccccttcccggcatcccgggcacatccc120<210>69<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>69tcacaggtcgtcttcccgtgacgcccagatctgtcctgcaggatggagccagcaccctca60gaggttcgactcgccgtccgggaagccattcatgccctctcgtcttcggaggatggcggc120<210>70<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>70tgtcatgtaatagggctcagtaaacgtcaatttccatagcatttcgagcctggatactga60aatatggggcaaaaagcaggaacatgcccctggtttggctcttgccttcttgcatttcct120<210>71<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>71gaacatgcccctggtttggctcttgccttcttgcatttcctgggtttcctcatttatctt60ttttttttttttttttggccttgttatctttctaccttcagggaagcctctcccttcttc120<210>72<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>72gatgtgaaaggttttggaaaggagatagccctgcagggcaggagggatttttaaggggag60gaagtgggttgggggaaatacccagtgaggagggaaacagatatgtaaattctacccttt120<210>73<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>73ggatttttaaggggaggaagtgggttgggggaaatacccagtgaggagggaaacagatat60gtaaattctacccttttctctacccaggcagatggctcttcttaaggccaataaggatct120<210>74<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>74acatggtgactgtggtggaggactggatgaacttctacatcaactattacaggcagcagg60tgacaggggagccccaagagcgagacaaggctctgcaggagcttcggcaagagctgaaca120<210>75<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>75aggggagccccaagagcgagacaaggctctgcaggagcttcggcaagagctgaacactct60ggccaaccctttcctggccaagtacagggacttcctgaagtctcatgagctcccgagtca120<210>76<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>76gaaagttggtgctgaggatgccgatgggattgacatggcctaccgggtgctggctgacca60cgctcggaccatcactgtggcactggctgatggtggccggcctgacaacacagggcgtgg120<210>77<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>77acatcactgtaccatcccctgggggccttcgaggtgcagtaatattcctggaactcgtag60gtaaaggatgcaaggactaaacaaggtaatgtgtgcacatggtttttcttctttcagaga120<210>78<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>78agggtgccccttcaatggctggtacatgggcacagagatcggagtccgggacttctgtga60cgtccagcgctacaacatcctggaggtaacccagccagcccagctggccagatgaaggtg120<210>79<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>79ctggcagttctaatcgatttctctgtccaagtgcttttgatattatcctgcaacaaatga60ctccccaacaaaaagatggcctaggaggctaggctaaataaaatgttctcttggagccaa120<210>80<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>80cgtggcatgcatcaagcacatcgtggactgcatccgggcagagctacagagcattgaaga60gggtgtgcaagggcaacaggatgccctcaacagtgccaagctgcactcagttcttttcat120<210>81<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>81cgagaagaatatcgaactcttcttttctggttcagcaaaaccaatctatgatgatgaccc60atctcttgaaggtaaggaatagtccgggattatgtttggggcacactttaaaaacagcca120<210>82<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>82ctgtccttagctgattggctgcagcctctgataaggcaaagcaaggcaaggcggcggggg60ggcactgtttctggggcacaaacttcacgttggcctgtctggggctggggttaaagacta120<210>83<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>83atgactggaatgggagaagtggattttctgacatttgatcctatagctaaaatggcaaaa60actgttaagtacgatgtacaagctgtagctatcattgtggtggtattgaaactgctcttt120<210>84<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>84cccttcgcacctctgctttgcggctttaacgcactacaccccacccaccacaagcacata60cacatgctctcaggagtcagagggtcacccagggctagaacttaagccacccagcccaca120<210>85<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>85gggatctatttccatatctacccaaaatctccaagccccttgttctatcagcaggtcaag60agtagagaactgtgacaagctgttctccattctgaaatggatttgactgaacagctgctg120<210>86<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>86tttaacgagggtgttcaaagtaaccatttcccactcccttatttatgagcagcagaatgt60aaaaagcaagaggcttaattttaatgcggtaattttctcatcaaccattctatctaagga120<210>87<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>87ttttccaaatatcatttctgttcaaaatggtaattttaaccttcttagcacccacaaaca60tttcccttctgatatctacttgaactttcagataaaaaaaaaaaagcaagttgcagtaac120<210>88<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>88caactctatagctgactttcaaccatggtcatctgcaaagaagttagtctcagccacctg60cgcatcctcaatgcaaaaagctaagttctaaaaacgtattcttaatgctgttttaaatgc120<210>89<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>89ctgaaagacggctagagtcttgaggagacccaaacagttaaaggttacagacagacttgg60ttccactccagtggtgggtgttttgttttgtttcgctttagctttattaaggtatactt119<210>90<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>90attctagaatttgttacaaatggactcatacaggatatcgtcttttgtgtttaatttctt60ccacagagcagaatgattctgggattcatccatggtgtggagtgtgttactctttcattc120<210>91<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>91ggtctcacacaacactccagggaggcagctgctgcccagtgctgtggacagcaaagcttc60agtgcaggaaattaagattccccctgcctccccctcccccatcctcatcagcttggccat120<210>92<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>92aaacctgagcacattcttacgcctagggcaataaatacatccttgagctacacaggctaa60gcaagagtgagagagggtgatgctgacaggccacatgggagagtgggaagacgtgggctg120<210>93<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>93aattcctagtttgggtcagaagaaaagggaaaagggagaggaaaaaggaaaagaatatga60cgtcagggggaggcaagtcagttgggaacacagatcctaacacagtagctggtacctgat120<210>94<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>94gataaccagcagggcctgtcagaagaggccctggacactgaaggctgggcacagccttgg60ggaccgctcacaggacatgcagcagtgtgtgccgacaactccctaccgcgacccctatca120<210>95<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>95ctggaaaactgagaggtttgcatgttgtaacaatgcaactcaagactatcagaatgatat60gaatatttgtatagatacttatcaaagcaacaatcagagatcaggtccctccaaatgagc120<210>96<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>96ctgctctcttcctgtgtgtctgtctggttacagggtgatctctgcagttgtactgagtgc60aacagctcttggaagagccttctcttacaccccaagttatgcaaaagctaaaatatcagc120<210>97<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>97tgggctcccagggtctcctctctccccttttagcccaggtattcccactggaccaggtgg60ccccacatcatgcaaaccttaatggggaaaacagaattaatactatatcttctcttttct120<210>98<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>98ttcagctcaaaagaaaacacaaattgggctttgatcctgaggtatacacatacagagtca60cggaggttttctgacaaaaactactcaacagatccacaagattcagccctttgagtgagt120<210>99<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>99tgaccatcccaatgaagagcagcagaaagacgtcacactgagagtatctggagaccttca60tgttggaggagtgatgctcaagttagtagaacagatcagtaagttactcttgctttacgg120<210>100<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>100ctctgattcagaagctcgtcaggtgggtcggaaagtgacgtcgccttcgtcttcatcctc60ttccagctcctctgattctgaatctgatgatgaggctgacgtttcagaggtcactcctcg120<210>101<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>101tagggagctggagacagcagagcctggggttgctaagttcctgatgttgcccaccaggct60attgctctgagcagcgctgcctcccagctttctggaaccttctgggacgcctggggtgca120<210>102<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>102caaccaaggaaagtcttccccagtccaaggagcagtcgtgtctgacctacattgggcttt60tctcagaactttgaacgatcccatgcaaagaattcccaccctgaggtgggttacatacct120<210>103<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>103tgtaatgtcacacttgagaacccctctggcttgctcagggttcattgtcttgtgttcatc60atagtctatgatgatgttgggtggatcaacaccaaaccaaatgaacacccctagaagctg120<210>104<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>104aattgatagtccctatgaaatcagccgtgccccagatgagctgcactacacctatctgga60cacatttggccgccctgtgattgttgcctacaagaaaaatctggtagaacagcacattca120<210>105<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>105tctttttcttctttttcttgtctatttacatgcccttgcatgaaacccctcttaaactgg60gatctgtgttctttttgttctggaacatacctaaaataaaaacattcttgaatatcttca120<210>106<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>106catcagctgtcgggctttggagctggaacacttaaactggtccacaagaaagtgctggat60atttgccatctgtttccagaaagcttccatctgtgaaatgagcacaagcagcaagaagtg120<210>107<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>107ttttcccctattattcttcaggtttttttgcccacctccttgtgtatatcttatgggcag60tggatggaagaaaaaaaaagaacaaatggaacgcgatggttgttctgaacaagagtctca120<210>108<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>108taacaatataatctggcatttaactgcctttataattaatgaaccttacttaaatcccaa60ttgtcgacaaaccacgtatgtattcagctcagtccagccatcatcacagacagttcccca120<210>109<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>109tatattttgtttttgtaagtttccacatgtatttttcttaccttcatgttgaagcaatat60cctttccaccatactgctagacgtagctacatctataggtcgcagaagctctgtattttt120<210>110<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>110gttgcagcacactgctgcctcaccattgtcatcgcacgattcggactggaaggagctcag60agactgcacttcagacaggctttcccgggcactgtatggctgggaaggcttttcctctag120<210>111<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>111ctctagggaaaagacccaggcgtccacgtctctgctcgcttcctcacctgtagaatatga60ttctgaaacccacagtggtactgctgtcaaagtcgcccctttcagcctgcacaatacact120<210>112<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>112catcattaccgtttcttcttttgctatgggatgagacactgttgagtattctctaaagtc60accactgaaatcttcctccaaaggaaaacctgtggaaaagccccttatttctgccccata120<210>113<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>113gcaaaggtagcatgatcacttgttccttaaatagggacttgtatgaatggctcgacgagg60tttcagctgtctcttactttcaaccactgcaactgacctgcccgtgaagaggcggacata120<210>114<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>114tgctcttactgagcgcatagctttctcagattatcaggaaccaaatttggaaaataatcc60agaacgctggcgtaggtagctcaaggttccccgcttgcaacatttagtccaaaccagtca120<210>115<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>115tgggaatacttcagtgaaaaatgagatacttattttctggattcatcctggtctgaatcc60aggcttgccaaatataccttgttattgtatgcacaaccaaaagaaatacacatttcatg119<210>116<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>116atgtgatgttgttggatatggccaataccatatgaagctaagtctagctgagtgttagcc60tgggggatactgccaggaacaaatgaggcccagctcccagtaatgggatatgtgtctcct120<210>117<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>117gattaagaaactctactgacacaacatcaggattaaattcactctggacagcagatgtta60ctatatcaaaaccacaaaatgttatcagggcggttccctcagaagacacttactggcaaa120<210>118<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>118agaaataatggaattatattggattatatgcaatatttgtaatttgtgttctgcttctac60aatagacatttttcatgtcattagatattttgtacaacatcaccttaaaaggcggtattg120<210>119<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>119ccttaaaaggcggtattgtatggatatacaataatgtaattaactgaacatatggttatt60tacagttttttcacaagcaaccctgctgtatttctgtgcacagatatagttaaaatcttg120<210>120<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>120gttcaagcaattctcgtgcctcagcctcctgggtagctgagattacaggcgcatgcaacc60acacccgactaattttttgtgttttagtagatacgatgtttcaccgtgttgctcaggttg120<210>121<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>121gtcttgcattgtgagcccatggatgggatctacctctggctgattggggtaggccatagg60acaggacatttaacatccccaaaggaccctgcagaacaagatttgtcagccaggactgca120<210>122<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>122gtgacccagagcgtccaaggggctggtctttccatggccccccctcatcacttcctgaag60cctgctgtagactgctataagagcggccctctctctctcttttttttttaaacaactaga120<210>123<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>123gggaatagagagtgatgggggtaagaaggaaaccagtttagaaagcgtggctggggaaag60actctttgtaaagtgatacatgagcagagaactgagtaagtgagggagataacctagtaa120<210>124<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>124tgggggtaagaaggaaaccagtttagaaagcgtggctggggaaagactctttgtaaagtg60atacatgagcagagaactgagtaagtgagggagataacctagtaagtatctggggacagg120<210>125<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>125aattctctattccatctgtgagaagagagcagagaagtttaaagtgtgtgaccttgagac60ggatttttcttttctgttctctgtcatccgactaaaagcaggaaagcagaggagtcatct120<210>126<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>126tcaccaagttaatagaaggacaatgatgcttcctttttctcctcaaaatcttccttcgct60actaaaaggtgtaggcacatagtttcatcatgaaaaaatattaatcaatagaatctcctc120<210>127<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>127actcttaacagtggcctggaataatataatggcttggtaaggacttaagagaaaatagta60agtgaaagatcccaaaagaactctcaggaatagttggggacacaggtcttccataaaaca120<210>128<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>128ccacatcgctggactcgttgcattggaagggacctggcctgcataagtgtcgaatctcta60tcagtggtaccattaacctcttaacaaacatctattctgtgtggagtactgtttcaggtt120<210>129<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>129cctgtgtgcatattataaaggtttgctaatcaaaagtctagagcacaaaaattaaaataa60ctgagctttgaggtctttagctattatgcctttgattagaagtttagtcagtgtaactat120<210>130<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>130tttcttaataggtgatttggggtaaggactccaaggaaacaagagcgttctgttctaaga60cagaaacatgaggcaaatggagacaaaaggagagaggagaccccaaggacaatagcctcc120<210>131<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>131tcagttaggagcaatcaaagttataaaaatgtttgagaaataaagactccaaacaaaaca60ctgaggccctcatcagtttgtctagggaaatgaggccagtagggggcctgaagatacatg120<210>132<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>132accaccaccaccactacctcctcttctggggcacaagacagaatgcctgtgctagagcga60tatttccacccagcagagctaggcaggaggtggacaggcccagaaggtgtgctgccctcc120<210>133<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>133aattttacaaatatttatggattgttcctttattactttttatatgtgagggaaagctcc60aacttgctttacctttctaagatatcccattttctctataccatttgttgactaatatat120<210>134<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>134accctcatagggtcatcattactgacaaaaagctggcatctcagatccagaccagtgtga60ggcaagtcaagaaggccctaatttagctgtgcaaacaaagcattcctgggtttgatacga120<210>135<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>135tagagaaaggctagttttggtctatcgcagtccatctaaccatcatgcccaggaaacagc60ccaagacttgcctgaagaaagcccaacttacaacttaaggccaagcaactggcaaccact120<210>136<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>136aaggaaagaaaccaggatcctggcagcccaggaagcagagccggtcatgacaacatgcag60ctgatgatgtggggtaagaaattggtactctaaaaactaattttgtgctctggagttttc120<210>137<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>137ccgcctctctgtgcacgtgaagaccaatgagacggcctgcaaccaaacagccgtcatcaa60gcccctcactaaaagttaccaaggctctggcaagagcctgaccttttcagataccagcac120<210>138<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>138caccctgtgcttggacccaggtcgtacgatcatcttcacaacccaccacctggatgaagc60tgaagcgctgagtgaccgcgtggccgtcctccagcatgggaggctcaggtgctgcggtcc120<210>139<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>139accgaagaattcgttatcatgtatggaaattagtgaatgactaaacaaggagctaaaaag60ataaaagagtgggatgattcgactagaatcttcaaaagacataggagaacccctggatat120<210>140<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>140cagctagagtcccctttcctggctgctgctgtctgtgggaacgtcctccacacccttccc60actttccagtatttaaagcgtgcttcctcttctcatccttcaggtcactgtgccagccct120<210>141<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>141aggacagatggccaactccaagcaatgttctttaggtaatatgcttctatagcatacttt60tttaaaattccaaacaaaattttttgcaggccaaagaaactttagaattttaggtctatc120<210>142<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>142atgggttgggactcattttaacttgagagatgtttgaggggccgaaaatgctccagaatt60tgtcgtgaccttgctgtattctacagaccaaactactatgcatctagactgtaccattat120<210>143<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>143caaatgcttaaaaccatgttgcccttgaggtttctcttctgtcttcatcgctttcccacc60gggcgctatacaggtcagggtaccgtgttacacattgtcttcacctgttccgactcctca120<210>144<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>144gaacgtctgtacaagtcgatgaagggtgcggggaccgatgaggagacgttgattcgcata60gtcgtgaccagggccgaggtaagacacactccgactccaaagaggcggctgcaacttctc120<210>145<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>145agggactgcgttccaggcacaggccacgctgaatatggcatcgttcatgttgtagcgggc60atgggggccctgcagggggaccggagggttaatgaagttcctcatgaaatctctccgaat120<210>146<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>146gtactctccttggagccggggtaatgctactccattcttatgagactgcagaacagctcg60tagcatctttgaaaccagatctccttccagcatctttgcctataagaacacagtagaagg120<210>147<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>147gtgcttgaccttcactcccttggtgaaggtccgcttcttgaggacaaagtcatagttggc60ggtagagttcatggcatagaagacgttggcgttttcagggatcttcagctctggtgggga120<210>148<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>148gtgtttcacaggttaccttttaaagaggaagccgaggacgatgccacagacaagggttcc60cacgattaggagcacataaatgtacacagagccgaggttcccgtcgtcagaacctggaga120<210>149<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>149tctgtcttagttggccctgctttggaaccagcacattgtttaataagctctgctcaaaag60ctgacttttttttcagattatgggtcaaatgcctggaaaggtgaggagaactaggtagcc120<210>150<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>150tccagttatactgtatttagggcattctttaatttaccaatgtattgttctgtttaaaat60gtggaaacctgaggaaatgaacaaagcttcactgggttctcatttttctgaagttccatg120<210>151<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>151tcaagacaacaacaacaaaacccagggaaacgtaccttggtgtgaacagcactgaatgat60gtttatgattgtatgttaatcctcttatatttaaaggttaaatgtaaaatatagcctttt120<210>152<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>152gttaaagcaaattactgtgcatatattgacccaataatttgatcaacggaacaagttgca60attaaacttaggttgtttccttgtttgttcacagatccctttttgttgtgtcagggccca120<210>153<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>153gctgattgaataggtgacaacattgccataggtatccattgggggtgcaaacctgtttgg60aatgagagttgtcaagacggttgagtacctgtaggagggattaaggatgttacttatctg120<210>154<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>154catagctagtctttgaacagagtaggtgctccagaatattctaagtgaaggagagaaaga60tttcaaatgtttgtaagcatggaagagtaaggcaatgatggagctactagcaaaggcaaa120<210>155<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>155gtgtttcacaggttaccttttaaagaggaagccgaggacgatgccacagacaagggttcc60cacgattaggagcacataaatgtacacagagccgaggttcccgtcgtcagaacctggaga120<210>156<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>156tgtctaatttatttttctggttactctcagaaataatttcagaaatgagtgtgacatctt60tccctgctgactgaaaccactaactttccacacaagggtaatatatatataggacattac120<210>157<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>157ataaaactttcaggaccctgaaatacagaactgcaaagaaacggcctaagatggttgaat60gctctttatttttctttaatttagacatgttcaaacgttcaatgtcttacatacttagtt120<210>158<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>158caaggacagtgtagcctgaactgggtgggaaaagagaggacagcaaggcctccagtgccc60aagggggcttgttggagttgaggggtgtcactgtagtttaggagatgagggtgtgtaagg120<210>159<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>159ccctctaatatgacctctaggtttacagcctcctgccatcttccagcctccaaaacccaa60aaattcaggccaacgctgaagctttatctgggaggggcatttttataggacccataacca120<210>160<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>160ttgacagttaatatcagccacaataagggaccttcaggagccgctttctagacccagggt60ctctgggaagcctcatcccacaccctctcctgctgtccagggccatctgggagctggtct120<210>161<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>161gagtgtccactgagtccgtttatttggcggtctgtctcactgggtttgcacgacagtttg60gacatctctgtgtggctccctgtggctgaaggcttgtcggattttccgtaagaggctccc120<210>162<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>162ccagggctgtctatgggtccgtgtttgatatttgggtggatctttgggaacgcgagtcca60ggagagggtccattcgtgggaaaaccacccagcattgtgtcacgcgcgtccgtgtgaag119<210>163<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>163ccaccaaacaggcttcttgtcccatccccagtcactaggagagtccaagtgccagggcag60ggctcaaaggtggcgcttcatgtgcaaggccaggtggtcagagcgcgaaaaagcacgtgg120<210>164<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>164acgtgggcagagctggcagcggaaggggcgctgccccgtgtgtttccggtagtggcgggt60cagctcgtccgagcgcgcgaatctccagccgcagccttcccacgtgcaggcgtatggctt120<210>165<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>165tggcttctcccctaggggacaaggaagccataagcgccactgtctgcccagtcatgtccc60cgggtcccctgcatctggccacacccctttactcagcctgggctgggactaggatgaaca120<210>166<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>166cccttcttcccctgtaactacagcgggcgccgcgccctttctcatgtccggggccccgcc60ccctcacctgtgtgcgtgcgcagatgcgccttcaggtgggagctcttggtgtagctcttg120<210>167<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>167ccgcaacccgggtgcgcgcacgtgtgcgctgcctgcctcttgcgcgcccacgaacgtcgg60cctcgcttggatggcgcggtctcggctatcacacctggatcctctgcagtccccccgagt120<210>168<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>168ccagtgcccaccgtcccgggtcccaaacaactcaggaaggagggggacgtggcgggaccg60ggcgcgggtccctggagcccgcggaagagctggaagtgcccttggtactgaggcgccggg120<210>169<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>169tacatcgcggggtacccggacagtagcccgtagggggcgcccgacgccgcaggcactgaa60agcccggtccgcgggaagtagccacccgaggagccggcgccgggccccgggtacaccggt120<210>170<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>170tgcagcgccagcgccttgggctcgggggccggggctggagccagggctgggcccacgaag60gcgtcgggagcccgggctcgcagggcagggcgcacccaacccgagtgatcctccgaaccc120<210>171<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>171aaaagcccagccaccagccccgggccgccagcatatgcgcccagagtctcgggcggcggc60ggatattgcgccccggaggcctcgctgggcgccagagcgcaggtctggggcgcgccaccg120<210>172<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>172ggctccgggcccgagaagttggtgaggaggagatccaggtcccaggtggcgtccgcgccc60ctctcatcgtcctcttcctccccgggctggtcctcagacttcacgtggaggggcggctcc120<210>173<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>173gtggggtcaggaggacccgggcccatgtcctgcgcctcttcggagcgccaccactgcggg60agggagcaggcagctcgaggttcggtggacactggggtgccctgcccagggacatcgcgg120<210>174<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>174taagtctcttgatttcaggtcaagatgcaggtctggaccccaagatctgtgactgtggcc60ctggattccagccagcccacctagaccccaccttctaggccccaccttgaggaagtcatc120<210>175<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>175ctgtgtgtccgggaaggggcccagggcggtcagtgtgctgatggagggcaaggcggtctc60ggctgtggccatggctggctggtgcccaccctgggcctcaagcctcctcttcctcggctg120<210>176<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>176cctcgtgaactctgaggctgtgatagccccttcgagggctcctctctgtccttagctgat60tggctgcagcctctgataaggcaaagcaaggcaaggcggcgggggggcactgtttctggg120<210>177<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>177ttaactgactgagaaaacactaaatttctgtctatttcaaagagaaagacttgataatgg60ctctacggatgtgtgagatcagttttaataggataacttttttttattattatacttca119<210>178<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>178gtgagccaccgctcccagcctagaataacttcttaaatgcttttattgttgactgaattt60atttctcccttgatagtttctactttgggttgataattaaataacagtgttatctctaag120<210>179<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>179cagtgttatctctaagattatatacatgtcttcccatatttttattctagttttttcgtg60actgaattttaccttcacacctaattgtgtaatcgattgtggtatatgcagttaagcatt120<210>180<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>180tatgcagttaagcatttcactttactcttttcaaaaagtatagttgttcaattactgttt60gttttttatttccaagctaaatttaaaagctatatttttatatatcacattattatattt120<210>181<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>181tcacattattatattttagtgagatttagtttttggatttctatttattccactatctta60cttacacatgagtggtattaatttaacatgattttagaatgaagaaaatgaagccatttt120<210>182<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>182aaaatgaagccatttttagataaaccaaaagtaacaatgtatttccagcagaaagagata60atattaaggataatcagaaaaaaatagaataaacttagagagaatgttagaaatgaagaa120<210>183<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>183tgttagaaatgaagaaaagcatgcaaaacattttgtacataagtgtaaacatttcttcac60tatttaataataacactagaaaatctagggagtaaaactatacaaaatatctaaaatata120<210>184<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>184atatatatataattatagattgggaaggggaaaatgaagataaagtgctaaaatttattg60tattgttttggaaaagagtaaacagtcaaatggatatttgtatctgaaaaatcaagaatg120<210>185<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>185tgctaaaatttattgtattgttttggaaaagagtaaacagtcaaatggatatttgtatct60gaaaaatcaagaatgcaattctaatcatcaagatgcatttttttattttttagtttttta120<210>186<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>186gacaagggtctgatttcatttcattttgagggtttcaccctctcatataataaaattctt60ctatatacccttctatcatcacttattactgattatatgccttgatttcagaatcttgcc120<210>187<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>187ttgccaactagattcagaatttgactgggagagaggacaaggaccacttgagactcatat60tttatttccagaatctagcatctacctacctaggtattgaataagaaaaatgaagttaag120<210>188<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>188ttaaggtggttgatggtaacactatgctaataactgcagagccagaagcaccataaggga60catgataagggagccagcagacctctgatctcttcctgaatgctaatcttaaacatcctg120<210>189<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>189tcctgaggaagaatgggacttccatttggggtgggcctatgacagggtaataagacagta60gtgaatatcaagctacaaaaagccgcctttcaaattcttctcagtcctaacttttcatac120<210>190<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>190catactaagcccagtccttccaaagcagactgtgaaagagtgatagttccgggagactag60cactgcagattccgggtcactgtgagtgggggaggcagggaagaagggctcacaggacag120<210>191<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>191gacagtcaaaccatgacccctgtttttccttcttcaagtagacctctataagacaacaga60gacaactaaggctgagtggccaggcgaggagaaaccatctcgccgtaaaacatggaagga120<210>192<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>192aaggaacacttcaggggaaaggtggtatctctaagcaagagaactgagtggagtcaaggc60tgagagatgcaggataagcaaatgggtagtgaaaagacattcatgaggacagctaaaaca120<210>193<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>193aaacaataagtaatgtaaaatacagcatagcaaaactttaacctccaaatcaagcctcta60cttgaatccttttctgagggatgaataaggcatatgcatcaggggctgttgccaatgtgc120<210>194<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>194tgtgcattagctgtttgcagcctcaccttctttcatggagtttaagatatagtgtatttt60cccaaggtttgaactagctcttcatttctttatgttttaaatgcactgacctcccacatt120<210>195<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>195acattccctttttagtaaaatattcagaaataatttaaatacatcattgcaatgaaaata60aatgttttttattaggcagaatccagatgctcaaggcccttcataatatcccccagttta120<210>196<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>196gtttagtagttggacttagggaacaaaggaacctttaatagaaattggacagcaagaaag60cgagcttagtgatacttgtgggccagggcattagccacaccagccaccactttctgatag120<210>197<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>197gataggcagcctgcactggtggggtgaattctttgccaaagtgatgggccagcacacaga60ccagcacgttgcccaggagctgtgggaggaagataagaggtatgaacatgattagcaaaa120<210>198<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>198caaaagggcctagcttggactcagaataatccagccttatcccaaccataaaataaaagc60agaatggtagctggattgtagctgctattagcaatatgaaacctcttacatcagttacaa120<210>199<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>199tacaatttatatgcagaaatatttatatgcagagatattgctattgccttaacccagaaa60ttatcactgttattctttagaatggtgcaaagaggcatgatacattgtatcattattgcc120<210>200<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>200ttgccctgaaagaaagagattagggaaagtattagaaataagataaacaaaaaagtatat60taaaagaagaaagcattttttaaaattacaaatgcaaaattaccctgatttggtcaata119<210>201<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>201tgtatcaattaaaaataaaagaaaataaagtagggagattatgaatatgcaaataagcac60acatatattccaaatagtaatgtactaggcagactgtgtaaagtttttttttaagttact120<210>202<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>202tgtgtaaagtttttttttaagttacttaatgtatctcagagatatttccttttgttatac60acaatgttaaggcattaagtataatagtaaaaattgcggagaagaaaaaaaaagaaagca120<210>203<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>203gcaaataaaagaaactaaaacgatcctgagacttccacactgatgcaatcattcgtctgt60ttcccattctaaactgtaccctgttacttatccccttcctatgacatgaacttaaccata120<210>204<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>204acttaaccatagaaaagaaggggaaagaaaacatcaagcgtcccatagactcaccctgaa60gttctcaggatccacgtgcagcttgtcacagtgcagctcactcagtgtggcaaaggtgcc120<210>205<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>205gcaaaggtgcccttgaggttgtccaggtgagccaggccatcactaaaggcaccgagcact60ttcttgccatgagccttcaccttagggttgcccataacagcatcaggagtggacagatcc120<210>206<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>206tggacagatccccaaaggactcaaagaacctctgggtccaagggtagaccaccagcagcc60taagggtgggaaaatagaccaataggcagagagagtcagtgcctatcagaaacccaagag120<210>207<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>207aaacccaagagtcttctctgtctccacatgcccagtttctattggtctccttaaacctgt60cttgtaaccttgataccaacctgcccagggcctcaccaccaacttcatccacgttcacct120<210>208<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>208cacgttcaccttgccccacagggcagtaacggcagacttctcctcaggagtcagatgcac60catggtgtctgtttgaggttgctagtgaacacagttgtgtcagaagcaaatgtaagcaat120<210>209<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>209atgtaagcaatagatggctctgccctgacttttatgcccagccctggctcctgccctccc60tgctcctgggagtagattggccaaccctagggtgtggctccacagggtgaggtctaagtg120<210>210<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>210aggtctaagtgatgacagccgtacctgtccttggctcttctggcactggcttaggagttg60gacttcaaaccctcagccctccctctaagatatatctcttggccccataccatcagtaca120<210>211<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>211ccatcagtacaaattgctactaaaaacatcctcctttgcaagtgtatttacgtaatattt60ggaatcacagcttggtaagcatattgaagatcgttttcccaattttcttattacacaaat120<210>212<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>212attacacaaataagaagttgatgcactaaaagtggaagagttttgtctaccataattcag60ctttgggatatgtagatggatctcttcctgcgtctccagaatatgcaaaatacttacagg120<210>213<211>116<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>213atacttacaggacagaatggatgaaaactctacctcggttctaagcatatcttctcctta60tttggattaaaaccttctggtaagaaaagaaaaaatatatatatatatgtgtgtat116<210>214<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>214acatacatatacatatatatgcattcatttgttgttgtttttcttaatttgctcatgcat60gctaataaattatgtctaaaaatagaataaatacaaatcaatgtgctctgtgcattagtt120<210>215<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>215ctctgtgcattagttacttattaggttttgggaaacaagagataaaaaactagagacctc60ttaatgcagtcaaaaatacaaataaataaaaagtcacttacaacccaaagtgtgactatc120<210>216<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>216caaagtgtgactatcaatggggtaatcagtggtgtcaaataggaggttaactggggacat60ctaactgtttctgcctggactaatctgcaagagtgtctgggggaacaaaaagcctctgtg120<210>217<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>217caaaaagcctctgtgacttagaaagtaggggtaggaggggaaaaggtcttctacttggct60cagattatttttttcctctagtccactaagaatactgcgttttaaaatcatttccttgat120<210>218<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>218aatcatttccttgattcaagttcctatttctctttatattttgtttgtttaaacctcctt60tactaaaatttactcttctttctctatagcttcccaacgtgatcgcctttctcccatccc120<210>219<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>219cctttctcccatccccctgtactttttccccttgtactaaattaactcctcaggtgagga60aaaacttttgaagtgcagagttctgcttcctgctattaaaagatgtaattaaaacagcaa120<210>220<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>220taattaaaacagcaaaggtagcaagcatttatgaggtcagcgtagggtctcagtgttccc60taagggccctgtcagtcatcctgaatcctgcccctacctggaaacccatgtcggtttagt120<210>221<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>221ccatgtcggtttagtaaggaaagtgttatacttttactttgcatgtttctcctacttctt60cctttcagctctaacactctgaaactacgattacacaaaataaaataaaataaaataa118<210>222<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>222acaataaaatgaaataaaatttaggttaaccaaaagaaactggatcctctatttctagtt60atcagaaggaaatttacaaatttcttatttccattgctttattctcttaaatgctttctc120<210>223<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>223tctattattgctaaataaatagagatctctcactttttctacctgtctcaaccctcatca60ggtacttgtgaaaaaatctcactctgattattctcacacacgcagaaagtgtttggttct120<210>224<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>224cttctatggctatctggagcctaggttaaaaaattatgcctatgtatgattatagaggta60agagggataaaatttaagtattttctttttatattcattcctctgtaaaaaactaaagca120<210>225<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>225caatgaggatctaggcacacgtgtatccctgagaaaagatttcacatgttgaatcctggg60aaaagacgtctttaaaatattttaaatgttaaaacatgcagatttgacttggctgttaga120<210>226<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>226agcattgttttagatttagacagttttcaagaccctgtttcacatccctgatataagagg60catgtatatgtgaaataaagtgttctgcggaagtttgaatatgtcttttgcaaatatcct120<210>227<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>227tcctgggtcaaagaaaatgcacagactttatgaaattataatataggttatatttatagt60attctgaaagaccaaaattgtcaaagcaagagctttgaaatcctgattggcagaaattgt120<210>228<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>228ttgtcaccttcttaaagacttaccctacaacttcttatgctcagaaatagttttcctttt60tctattttgttttcttttttaaatgatgaactatggatccttctcttgtgttggcaactg120<210>229<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>229actgctgcagataccatcatcctggcttcaaggcaggggttgcttttccaatggtagtta60cttagtgtgactagagtgtaacgcagacttttctttctattacccataataccctgcagg120<210>230<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>230cagggacaaggctgcaagctatactaagaccatcaaaagcccaggcataccaggcaaata60agtttcaagaagcaataaatagtgcaaatttggttatggtcagagcctcagtttcaaatc120<210>231<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>231aatctaaatcagcattcaaagttcctgaaaaactattcaagcttactgacatcttcacta60ttgtgagcttgcttctactctgtgaatggatgccacagcaggtgcaggtctattctactt120<210>232<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>232acttttattccagccccactgaccacaacacacacacacacacacacacacacacacaca60caagtcctcaaaaaagagacagcgagagagacagaggtccatttcctttactccagtcta120<210>233<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>233tctattaatctttcttaagtcctaatgttttatatcagaatggccctagtctgggtatac60ttagaggatgaatattaacttcctccatgaaaatcatgacactcatctatgggagtgtgg120<210>234<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>234gtggttttatcatttgtttcaaaagcagcacttgactagagtatttttatacatgctcta60ctgtttagtctaaaattccccaagtgagacattttagcaatctactgtatatgttcctag120<210>235<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>235ctaggtcaagcacagtctagctacttgctacagacttctctcgcagatacacaatctctc60agtaaacacaactcagcagctctcagaattaattaattaaaatgaaataaaaatgctcca120<210>236<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>236tccaagaaaaccagaacccatagaaacaaaccgcacacacacaaaatagtttggaaatag60gatagtttagttcactttaaaaagttgtatttcttaccaaaaagcaataaagtcaacata120<210>237<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>237catagacagaactttgctaaagtatatgcataattattacagaaaaatttatatttcagt60ctgcaccttgttcattaatatttcctccactgggctcagattttcattcagaattagctt120<210>238<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>238gcttttttttaacctcattaagtgggccatggtgtcaatttatggagagcagaggtacag60tcttcagataaatttgagattgcatctctttagaggtagaatcttggcttcagtctgaac120<210>239<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>239gaacaccctttacaaacatgtaggcattaattcagaggactgctctgaagctcaagagat60ggatgatttaggagactattaggcttaattctcctgacattaaattattttattgaaaaa120<210>240<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>240aaaattttcatgaactcaaattcacattattacgtcctctcttcccttcctctctccctc60tctttcacacacacacacaccctttcattcagacatactgaacatagtttataaagcaac120<210>241<211>114<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>241caacgccatagtgagaaaagaaaaacaaccatttgataaattatcaaataaaattaaagc60caaatcttgaggaattaattccattcctatactttgttttaactttcattttaa114<210>242<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>242tatcatcatttagctcccacactcctagactcttacaaaagctctactctaacaaataat60tttaatataacaacaaggtgccaagtcttttttcatctcttgacctcctcatcttcaata120<210>243<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>243ttcaatatgaagatagcaatgcctagcatatagtaattgtgtgtgctcggcacatgtccc60atccaggtgatgttctcatgaattctctggtatttggatttttagggccaacatcttgcc120<210>244<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>244tcttgcctagactcactgactacttctaatggtgtaggaatagaaggtatagtaagctat60atttgctctttttttttgacttttggagaaaggaatgtagtttgttttccctatcaagat120<210>245<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>245tcaagatcataaggtctacaatctctcttactgtctttcgaataccacacaagtatctcc60ttttaatatcttactcttatgagaacttccctatgctcaggaatgtgaaagtgatcttcc120<210>246<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>246atcttccccaaaatgccctgagtagctctgcttctgatatgtaaaccagtggttcctaaa60tatcttattcagatataaagagttctcagtgcctactatgtataatgacttaaggaaaac120<210>247<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>247ggaaaacacatggatataaaagagcttctgctgccagtcaattcaaaatgttgtgatcaa60aacagttaactataacacattgtcagtatattctggcagtacagacagagttactgtgaa120<210>248<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>248ctgtgaaagcactttcaaacacaaggaaacaacagattctgtttaggtattcaagtaagt60ttaaaattaatcaacatgcatataatacagatttttaaaaatgtatacaactgagaaagt120<210>249<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>249agaaagttctaaaaatccttctaattttacctatggcaaaaatggtgctcaaggaaaaaa60atattactcctatgatcagaaaggaaataactgttcggttgtttactgcatgcttcctct120<210>250<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>250ttcctctttgtatgttgtagcattaacaacaaagaaacactgtgcgatggtattattaat60attgtcctctaattccagaagttctaaagcaaggaataatcattccttcatttactcatt120<210>251<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>251ctcattcgttcattcattcactgttttcttgaataaatattttctttctgcccattgatg60aatttaatatgaggcacagtaggcatgtaagaaggtagagaataggcagaattgcttata120<210>252<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>252aaagcacggagtgtgtgtgtgtgcatgaaataaataagaaaaatataaaaatataaaaaa60tggtgtgggggagggtttggaaagattttttgggtagtatagagaagtttattgtggctg120<210>253<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>253ggggtcaagagaggtcacaagtaatacgtgagcaatgaatcttgactgaaatatgggaag60ataagaggaaattctttacagagatgttctggggcaagtaagaggaggaagctatttctt120<210>254<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>254tggagcaggaacacttgatggggtatagtattatgggctacaatgtgcaggcaaaggaag60gaggaagaaagacaacataacattgtcttgagtaatcattatgcctttaattgagcacat120<210>255<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>255ttattttctcagtaattgttggagtttaatcgtagcattacccttgaggctatgtcttag60ggttgaggtcttccctagaacctctgcagtgccagtattatctttgtatcaagagttctt120<210>256<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>256tgataatttctgctctttggaggtagaagtgtcacccattaatgccttgtacggttccct60tgcttttctcttttcccatgtactctttgtaaaataaacaagtgctccctatctgtagag120<210>257<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>257gcctcaggaaccttcttacacacctggacaaaaaaatgaaataagtgaaattaatcagga60agttgagctgaacattctttattaggcagaagccatacccttgaagtaggcattgtgttc120<210>258<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>258cccaagttcagaaaatagaatctagggaaatagggtcttcttatggttatcaggaaacag60tccaggatctcaatggtacttgtgagccagggcattagccacaccagccaccaccttctg120<210>259<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>259gataggcagcctgcatttgtggggtgaattccttgccaaagttgcgggccagcacacaca60ccagcacattgcccaagagctgcggagaagaggtaggcagatacatgcatatggttaaca120<210>260<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>260agagaaataaagactggcttctgagaaactgagccaacacccatttttttctgcccaaat60cttagacaaaactgatccccaggttattcccatcagcataaataagtacatatatgaat119<210>261<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>261atgctgtataatactatatacaaattaattccaaattagttttaattttgtatgtgtata60tagcatatacaaattaattactataaacagattaatagatacaaattaattgattaatca120<210>262<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>262tcagtgtgatgatgggctgtctcctagcaacgacttctgccccacctccagtgtaactgc60ctagtctttcataatcaaatattcactttcctttccattccatttactacagaatttata120<210>263<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>263ataaaattccaattattccttattgtaaaatgatttatagcctctaaaacagtattctat60gcctctcatctttgagttggagcctctcccatacccatgtggagagacaaaaggattatt120<210>264<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>264attctaagtgcagaattagcaggtgagagctggtatgcataatttgagttgttgttagag60aaggaaaaatgaagggagggggttgggagagaaagacaggatattaaataatttaaaata120<210>265<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>265atagcaagattgtgaggaaggaaaaaatgcagaatatttaaataaaaaattaacaaaatt60ttagaagcattaaatgataaaatatagtaaaatgacaaaaatgtgggagaagagcaggta120<210>266<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>266gtaggtaaaagaaccaaaatgtaagattagaaagtaaaaagagaaaagtgaagcatctcc60tggactcaccctgaagttctcaggatccacgtgcagcttgtcacagtgcagctcactcag120<210>267<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>267cagctgagaaaaagtgcccttgaggttgtccaggtgagccaggccatcactaaaggcacc60tagcaccttcttgccatgagccttcaccttagggttgcccataacagcatcaggagagga120<210>268<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>268ggacagatccccaaaggactcaaagaacctctgggtccaagggtagaccaccagtaatct60gagggtaggaaaacagcccaagggacagagagtcagtgcctatcagaaacccaagagtct120<210>269<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>269tcttctctgtctacacatgcccagtttccatttgcctccttgagcctctcttataacctt60gataccaacctgcccagggcctcaccaccaactgcatccacgttcactttgccccacagg120<210>270<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>270agggcattgacagcagtcttctcctcaggagtcagatgcaccatggtgtctgtttgaggt60tgctagtgaacactgttatgtcagaagaaagtgtaagcaacagtcgactctgccctgcct120<210>271<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>271ccttttatgctggtcctgtcctccctgctccagtgagcaggttggtttaagataagcagg60gtttcattagtttgtgagaatgaaaaatgaaccttcattccactattcccttaacttgcc120<210>272<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>272gccctgagattggctgttctgtcatgtgtgtcttgactcagaaaccctgttctcctctac60atatctccccaccgcatctctttcagcagttgtttctaaaaatatcctcctagtttcatt120<210>273<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>273atttttgcagaagtgttttaggctaatatagtggaatgtatcttagagtttaacttattt60gtttctgtcactttatactaagaaaacttatctaaaagcagatgttttaacaagttgact120<210>274<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>274actcaatataaagttcttctttgcctctagagatttttgtctccaagggaattttgagag60gttggaatggacaaatctattgctgcagtttaaacttgcttgcttcctccttcttttggt120<210>275<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>275ggtaaattcttcctataataaaactctaattttttattatattgaaataaatatccatta60aaagaatatttaaaaaatgaatagtgtttatttaccagttattgaaataggttctggaaa120<210>276<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>276aaacatgaattttaaggttaacattttaatgacagataaaatcaaatattatatacaaat60attttgaatgtttaaaattatggtatgactaaagaaagaatgcaaagtgaaaagtagatt120<210>277<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>277atttaccatattcagccagattaaatttaacgaagttcctgggaatatgctagtacagaa60catttttacagatgtgttcttaaaaaaaaatgtggaattagacccaggaatgaagatccc120<210>278<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>278cccagtagtttttcactcttttctgaattcaaataatgccacaatggcagacaaatacac60acccatgagcatatccaaaaggaaggattgaaggaaagaggaggaagaaatggagaaa118<210>279<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>279atgactttatttgtatatagaaagatggatgatgtgcctgagattctgatcacaagggga60aatgttataaaatagggtagagaggagccatgaatgacctttaaactttgttacaagtta120<210>280<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>280cctgagattctgatcacaaggggaaatgttataaaatagggtagagaggagccatgaatg60acctttaaactttgttacaagttatttttctgtaacctggaagccaacgaaagatattga120<210>281<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>281gctgggcttctgttgcagtagggaagaaagtgacaatgccatttctattatcagacttgg60accatgacggtgatgtcagtcgtgaacacaagaatagggccacatttgtgagtttagtgg120<210>282<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>282acatttgtgagtttagtggtacgataaaatcagaaatacagtcttggatacattgtattg60tatgcactcttgtaaaatgcaaaaagatgtacttagatatgtggatctggagctcagaaa120<210>283<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>283tggatctggagctcagaaagaatacaaccaggtcaagaatacagaatggaacagaacata60caagaacagatcataatgtgctgtgtgaatcactaccactacctgttaaaaatgacagat120<210>284<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>284cctgttaaaaatgacagatgatgtacttcatcaatatctccttaaaatcttagaatgtg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caattttctacgtttccctatttattatg120<210>309<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>309atgtcactctcatatgcaagaaacttcagtgatttttgctcaaaacgatagctatttttc60ttacttcatctggtctctgcatccagtttccctaattttatatcatcctgcctcttttaa120<210>310<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>310taaatgtccatattctcctctatcaacttgacttaacgtgctgtttcctaaatctcagcc60ttttaatctgctgtttgctcacataaacaaaaatcagtggttttcaatattgattgctaa120<210>311<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>311taataattttttattcataaaaattgtatatatttatgaatgcacacatgtgtgtgtata60tatatagaaagagaataaaatcactaccactaaaaacaataaaacttgtacatatttata120<210>312<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>312atagaaacagagagctgaacaaagagatttattatttattgggtagtgtgataaagactt60tacaggtatcaattcaattagttcttacaaaaatcctttaaggaaaatacatatgataaa120<210>313<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>313aaatctatcatatgcacagcttaatggaattataaatatgtttcaggtcacagaggtagc60agatgaagtacagatgaaaaccaagacagccagttcacatgccttagagataattctcta120<210>314<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>314ctattaataccattgaagacgttaagagaaagttcaaggtttggcccttgattggtctct60aggaagccccatccccacttcattataaataataaaaaatatgttgtttaaaataagtag120<210>315<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>315tagaagtgaactgcagtcaccaaatgagctatatcctgagtttcatacaaataatagcct60atacagaacttctaatttgagtcctaacatacctctacacactaccaacaatcctcttac120<210>316<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>316tacacctccaaagagtacctccattgacctccctttctgtaaaaacattgtcttattcta60gagacgatttccccttcctaggagtaactaccccactaaatccacccacgagttctctct120<210>317<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>317tcttttcttgcaggattgcaagaaagtatcttctctgtccttaaactcccattctccaac60attctcatttccatcagaaatagtgcgtccttttggctgaatcagggtaaaatataaaga120<210>318<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>318agacagaaaaagagtacaatgatatttcttagagagcatatttctttattctatttttat60catgcaggaactgaatcagcaggcaggatactgctcttctccccaacctcccccatctaa120<210>319<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>319taaaggagatgagattttgggacataggtacaaacatagtggaccataggtacaaacata60gtggacagggaactcagtggtcttgtgggctacagcattaaccacagcatttgttagtta120<210>320<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>320ttactgccaagaagcctgtatctgtagggtaaaatcctcgctgaagtgggttgccaaaac60aatcaatatcacgttgcctaagagctggggagggagtgaagataaaaaagaaaatggtac120<210>321<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>321tacatagtgaatagaaggcctcaagctggacttgcagtaaatagatataacacttacatc60ctttttcaccagagtttgagcaactctcaccattatgggctagatatcagcttcaatatg120<210>322<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>322atgactggcagccctgcacctcccattgtgtcctatccttctcttacttgctatgccaac60tcactaccccaacatattgtgattgtttcattttttttttagagacttcgtccttttaaa120<210>323<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>323aaaaagtaggataatagtacttcaaggaacagtaatggataggataagtccccagtcatc60acatacatacatacatacatacatacaattttcccaaacactcataacaaagaatcctgt120<210>324<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>324tgtaccatgcgtacaaaagtataccatcatcattcggagggaaacaatcctctttttaac60agcttcccactactttgttcagttgatctttttctaacctccaggactatgcagaaaagt120<210>325<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>325agtgactattaatttttatagaaaatttcgctgaccaaaggaaagatgttattttctcta60tctcaacttctgttccctcatccaaaaacactcagtttgattttggccagaattttttat120<210>326<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>326tataagatgtgtttttcagagctatcaaatggtaagtggccttccattattcatagtcct60tgctctaccaaattttagttatgttatttacagcaacataactctcaaaatcccactgct120<210>327<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>327gctgaaatatcatatcccatagctgactcataacacaagagaaagccacctctgctttca60aaagtacccatagtgcaaatatctaagggtaaagaagaaagcgtgagtgtacttactact120<210>328<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>328actcaccaggaagttctcagggtccacgtgcagcttgttacagtgcaggtcactcagtgt60agcaaaggtgcctttgaggtcatccgtgagcataacagcttttccgaaggagatcagcac120<210>329<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>329caccttcttgccatgtgccttgactttggggttgcccattattgcacagtcagagcccag60atatccaaaactttcaaagtacctctaggtccatgggtagacaaccaggagactgtggga120<210>330<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>330ggatagtcataatcacagagcaggtgcaaagtcagactatgtaagacaacgggctaatcc60ctctttcagaaacactttctgcctttctgcaccttgtcccggcttccagtacctacctgc120<210>331<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>331tgcccagaatctcacctccagccttctcaccttaaccttgcttcacaggctggtggcagc60agccttcttgtcagcagtgaaatgcactacagtgtcagatctgggagtttcctggtgatc120<210>332<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>332atcacagatgagccagaagcatgcctgcattgctgcttcatgtgtggctttttacttctc60ctctctggcccccagccctttgcctctcccagtgaaatgaatctattgaccagccctttg120<210>333<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>333ttgcctccctcagtaaaatgaatctattggtcaagggtgggttgtgactccaggggtggg60gtttgggcaaggaagttttgcaagatggacattcgagtttctgatagaatccaggtggcc120<210>334<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>334gccttctcaggggaactttgctgttcaggcttaatttgaaactttacttccttcccctcc60attttcctacactacccccaccatccagtgtgcagtttatttctcaaggacttcgccagc120<210>335<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>335agcagccgctaataacctgaatgctgacaaataggaataagttacaactgaaaaggataa60gaattacgaatatcttagccatcaattcctggatcaggagttgtgacaatgtaacaacgt120<210>336<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>336cgtgttatcctgttattcatccaggctttatgtggaagaagccacagcctttcttggttt60tcaattctcttgagactacattgaatacacaatttcatcagtttttttttctttctttct120<210>337<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>337gtgagccaccgcgcccggccaatttcatcactttttagaatagaaataaacacctctatc60cagcatcaacttggaagaaagcagaataagaaacaaactagggaagtaaggggaaaactg120<210>338<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>338tgggttttattactgtgttttttaatccatttagtagtcagtgtacttatctgaacaaag60gagatttcctctgaatcattgaacaatagtccatgtcaaatcctacatatctacaaaatt120<210>339<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>339ttatgccagaacatctaatagtgttgggggagaagtgtgctgctctgttcaagcaagagg60ataggagattccgtggcccgtgctgggcattaggtcatttgtgtctggcacaggcttgat120<210>340<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>340atctatagtctaatgctgtgtttaacttgtctttatatctaatcaggcaaagacattctt60cactgacaatattccacaggctgctgcacgtgtctcatgtgctgcacgtctcatgcgtct120<210>341<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>341ctcaaacaagcaatttcaggaatagacagggcacacttccaccggcagagagaagaacag60tttattttatattcttaaggcttactgtcctcatacttagaggttcaggatgctggtttg120<210>342<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>342tgtgtgttacccctgagataaatccttacaagaaataaagtttaggaaatcacccccatg60tgtatttcaaggagactctaaatttcaaagagttaaacccaatatattaaagctgaattt120<210>343<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>343ttctgatattagagacacaatattttagtctacttgatatagttgagaggcagttacctg60ttttacttaggaacatggggaaagtttgtagtgacaaacagtttgaggcaaaaccaagat120<210>344<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>344attatctttaagagcagagatcgatgatatgaagaaaaagaagtggcaactttgactata60tgcaggaaacacatttatattgagttgtggggactggcctcagaggaaacttcaggtcat120<210>345<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>345atgtcctttaatggccctaaaactcattcccaaaagaatttctgttcattgccatacctc60atatccttaggtacatacatctaaaaccctgcgtaccagtgaacagctgccccatctttc120<210>346<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>346tccatcagccaaccaggaattcagcagttactgctaacttccacttttctctcacccgct60ccaggaaaagtgacctgcagtcactttcctggaagtattgattctttcttgtttgtggct120<210>347<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>347ctgttccccatttccaattgttttccatgattattgcttctactgtgatctatagactct60tatatcatcaataccaggttatcattgcagttgtcaacttctctctgttgcatcttatgc120<210>348<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>348gcattaattcaacaaatacatattagattccatatgtcatccatgaagtttcattcatat60gccatccatttttcttaattctgagaatcttacatgaactagacagacagattctctggc120<210>349<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>349gctaatggtgccctcactatagtgagcagaggagaccagcatacatactaaaagaaatga60attaataagagatttcagatggtattatatgacttgaagaaactgcatattgtacctaca120<210>350<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>350aagaaaaaaagaataaagaactttacatttcactgtatgtaaagacattacaaggctaga60gtaaagcatgttgaagtaaaaataggagaaatcaaagttagagagaagggcgcaggctta120<210>351<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>351taggagaaatcaaagttagagagaagggcgcaggcttattatttgggtcttatagatgag60agtagtagagtaggtattttatactgaaacataggggacgaggggagctttgcaaacctg120<210>352<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>352actgaaacataggggacgaggggagctttgcaaacctgagataaacatggtctgtagtcc60actcaaaacccaagcttatttttttctccttcttcatctgccttactcagtgcaaggtgc120<210>353<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>353caaacattaggtccgtaacaccatcatattaaactcttacttatagagatgcactaacat60ccaactatacaaaaattccattaagtaagccttccaattaatgttgtacaaattcttccc120<210>354<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>354ttcccactacattttgatctcacagtgctggtctgtttctcagacataacatgctcatgc60tgacttgtgagcctctgctgattcatttcttacacctaagtccccacctcccccagagtc120<210>355<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>355gagtcttacaatgaggtctctcccttgaaatgctgtgaccaatctgcacacttgagggca60tgggattaatttcactttcttaggcatccacaagggctgtgaaaagctaagtgccattag120<210>356<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>356attagaaatagtattcctcctaataaaatagaattgctacacctgactaaaccttgaatt60cctaaagcttggaacactttcccttccttaagaaccatccttgctactcagctgcaatca120<210>357<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>357aatcaatccagcccccaggtcttcactgaaccttttcccatctcttccaaaacatctgtt60tctgagaagtcctgtcctatagaggtctttcttcccaccggatttctcctacaccattta120<210>358<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>358atttactcccacttgcagaactcccgtgtacaagtgtctttactgcttttatttgctcat60caaaatgcacatctcatataaaaataaatgaggagcatgcacacaccacaaacacaaaca120<210>359<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>359gcagaaatacacatacacacttccctcaatataaaccctttgtggctcatatatttaaaa60agatgtaaaaaaaagagctgaagaaaatcatgtgtgatctctcagcagaatagatttatt120<210>360<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>360attatttgtattgcttgcagaataaagcctatccttgaaagctctgaatcatgggcagtg60agctcagtggtatctggaggacagggcactggccactgcagtcaccatcttctgccagga120<210>361<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>361ggaagcctgcacctcaggggtgaattctttgccgaaatggattgccaaaacggtcaccag60cacatttcccaggagctgttgagatgaaaggagacaataaagatgaacccatagtgagct120<210>362<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>362gctgagagctccagcctggcctccagataactacacaccaagcttccacccagaatcaag60cctatgttaacttccctcaaagcctgagattttgccttcccattaaatgcaggtagttgt120<210>363<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>363tgttccccttcaagcactagtcactggccataatttaaatcttgctatcttcttgccacc60atgaaccctgtatgttgtaggctgaagacgttaaaagaaacacacgctgacacacacaca120<210>364<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>364cacacacacacacacacacagagctgactttcaaaatctactccagcccaaatgtttcaa60ttgttcctcacccctggacatactttgcccccatctggaattaaaggatataagtttgta120<210>365<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>365gtaatgaagcattagcagcattttatatgtgtccagctgatataggaatagccttagcaa60tgtatgtttggccaccaaagttccccactttgactgagccaatatatgccttctgcctgc120<210>366<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>366tgcatctttttaacgaccatacttgtcctgcctccagatagatgttttaaaacaacaaaa60atgagggaaagatgaaagttctttctactggaatctaataaagaaaagtcattttcctca120<210>367<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>367tcatttccacctctcttttctcaaagtcaaaattgtccatctagatttttagaggcactc60cttaggccctaaaacattaccactgggtctcagcccagttagtcctctgcagtttcttca120<210>368<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>368tcacccccaaccccagtatcttcaaacagctcacaccctgctgtgctcagatcaatactc60cgttgtctaagttgcctcgagactaaaggcaacagggctgaaacatctcctggactcacc120<210>369<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>369accttgaagttctcaggatccacatgcagcttgtcacagtgcagttcactcagctgggca60aaggtgcccttgagatcatccaggtgctttgtggcatctcccaaggaagtcagcaccttc120<210>370<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>370ttcttgccatgtgccttgactttggggttgcccatgatggcagaggcagaggacaggttg60ccaaagctgtcaaagaacctctgggtccatgggtagacaaccaggagcctgtgagattga120<210>371<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>371tgacaagaacagtttgacagtcagaaggtgccacaaatcctgagaagcgacctggacttt60tgccaggcacagggtccttccttccctcccttgtcctggtcaccagagcctaccttccca120<210>372<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>372ccagggtttctcctccagcatcttccacattcaccttgccccacaggcttgtgatagtag60ccttgtcctcctctgtgaaatgacccatggcgtctggactaggagcttattgataacctc120<210>373<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>373ctcagacgttccagaagcgagtgtgtggaactgctgaagggtgcttccttttattcttca60tccctagccagccgccggcccctggcctcactggatactctaagactattggtcaagttt120<210>374<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>374tttgccttgtcaaggctattggtcaaggcaaggctggccaacccatgggtggagtttagc60cagggaccgtttcagacagatatttgcattgagatagtgtggggaaggggcccccaagag120<210>375<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>375gaggatactgctaattttttttatagcctttgccttgttccgattcagtcattccagttt60ttctctaatttattcttccctttagctagtttccttctcccatcatagaggataccagga120<210>376<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>376ggacttcttttgtcagccgttttttaccttcttgtctctagctccagtgaggcctgtagt60ttaaagctaaagcatgtaccaatttttgaaaagttcagggattgtgaaatgtgttttagg120<210>377<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>377aggcataggtccaggatttttgacgggacaaatcttagtctctttcagttagcagtggtt60tctaaggaaaaagtgctatacttctttttgaatatactctttgtgacttttgccattatc120<210>378<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>378atctcttaatttctcaatagtgcagtgaaaacaatttctataaagccacagtttcagcgc60agtaatagattagtgttacataatataagacctaatgcttacctcaatatctacttatcc120<210>379<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>379tccgtacctatttgaaataaatcatgactgtttcatcttagaaaaatatttgattccata60ttcaggtatgtatgtatacaccagatgatgtgtatttaccactggataagtgtgtgtgct120<210>380<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>380gctggctgatgacccagggttttggcgtagctcttctatgctcagtaaagatgatggtag60aatgttctttggcaggtactgtggattagaattaattatcttgtataaatgctaggttca120<210>381<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>381tcacttctcagggaatcttactctaagacataagatgtgcgtgtacatggaaaacaactc60taaagaggcaagggttgtttttattgactaatagtccacacactattataactcgaatat120<210>382<211>112<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>382tattagtgtactttagacagctttatttctaacacagtgctgtttctgacatattggacc60attaacagggtaggaagtatttatggtggttttttggttctgttttgctttt112<210>383<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>383gttagtttgtttttgtttttctctgaaagtgatccatgatctctaaccttgctagattat60aatgccagaagctctggaattctggcttatcggaggcaagctgtatcttcaaattagttt120<210>384<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>384ctctggaattctggcttatcggaggcaagctgtatcttcaaattagtttatcccctaagc60tatcaggttgattgaaattattataatattggtgaaattctttcatccttcatgatcctg120<210>385<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>385ttgaaattattataatattggtgaaattctttcatccttcatgatcctgtgtaaagctta60tatctgctcattgatacagatggctaaaaggccagaaagacacacatttacccatgtaac120<210>386<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>386attttttataaacttgttttactaaaaaaaaaaaggacaaagaaagaaagtgcgaattgt60gaaatggtagtgagtgatggcatttgaagtgggtcctttatgatttgatggagccaggca120<210>387<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>387cagaagacgtttggagaaagaagttcctgaaagtaggaagggcatgtggaaaactctgag60gctgaggaaaaaaaagaaagaaagaaatataaagaaagaacttgacatttcactgtatat120<210>388<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>388ataaacacattacaagcctaaagtacgttgaagaaaaaatagaattcaaagttagacaga60agggctcaggcttactatttgcatcttacagatgagagtagtagagttggtattttattc120<210>389<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>389tctgaaacacagaggacaagtggagatttgtaaacctgagataaacatggtttctaatcc60actgaacaccgaagcttatttttttctctttcttcatctgccttacttagtgcaaggtgc120<210>390<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>390caagcgttaagttcataacaccatcacattaaactaaactcttgcttattaacgtgcatt60aactttcaattatataagaactccagtgaatctgccttctcaattaatgttatacaaatt120<210>391<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>391cttcacactatattttcatctgaccgtgctgttctgctgctgagacatgacacgctgatg60ctgacttgtgagcttctgctggctcatttccttcacctaagtccccacctccctagaagc120<210>392<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>392ttacaatgaggtctcctccttgaaatgctgtgaccagtctgtagacttaagggtatggga60ttaatttcacctctttaggcatgcgtcaacacttaaaatgaaaagttccttagtaaagta120<210>393<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>393aggatcacttcattgtagttaccgtggaaagaaaaacctgtttcctgctctgatctctaa60cacctcaacctccctgtagagcctcacaagggctgagaaaagccagatgccgttggaaat120<210>394<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>394agtattgcccctaataaaatagaatggctatccctgcctaaaccttgacttcctaaagct60tggaacactttttcttcgttgagccccttcctcgctgctgtgctgcaatccagggaaggg120<210>395<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>395ggttcagcccccttcactgaacctttccccatctcttccaaaacatctgtttctgaggag60tcctgtcctatagaggtctttcttccaaccagatttctcctgcaccttttactcccactt120<210>396<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>396gcagaactcccatgtacaagtttctttattgcctagttcttttatttgctcatcaaaacc60cacatctaacgtaaacaaaaaagtgtggagtgtgcacatgacacaaacacacatagccat120<210>397<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>397gtataaatacacataaacacatccctcaacataaaaccctttgtggctcatatatttaaa60aagacataaaaaaagaactgaagacaaccatgtgtgatctcttagcagaatagatttatt120<210>398<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>398atttgattgcttgcagaataaagcctatccttgaaagctctgcatcatgggcagtgagct60cagtggtatctggaggacagggcactggccactccagtcaccatcttctgccaggaagcc120<210>399<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>399tgcacctcaggggtgaattctttgccgaaatggattgccaaaacggtcaccagcacattt60cccaggagctgttgagatgaaaggagacaataaagatgaacccatagtgagctgagagct120<210>400<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>400ccagcctggcctccagataactacacaccaagcttccacccagaatcaagcctatgttaa60cttccctcaaagcctgagattttgctttcccattaaatgcaggtagttgttcttcttgca120<210>401<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>401gcactagtcactggccataatttaaatcttgttatcttcttgccaccatgaaccctgtat60gctgtaggctgaaaacgttaaaagaaacacacgctctcacacacacacaaacacacgcg119<210>402<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>402cacacacacacacacacacagagctgactttcaaaatctactccagcccaaatgtttcaa60ttgttcctcacccctggacatactttgcccccatctggaattaaaggatataagtttgta120<210>403<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>403gtaatgaagcattagcagcattttatatgtgtccagctgatataggaatagccttagcaa60tgtatgtttggccaccaaagttccccactttgactgagccaatatatgccttctgcctgc120<210>404<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>404tgcatctttttaatgaccatacttgtcctgcctccagatagatgttttaaaacgaataac60aaaaataggggaaaggtgaaagttctttctaccgaaatctaataaagaaaagtcattttc120<210>405<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>405ttcctcatttccacctctcttttctcaaagtcaaagttgtccatctagattttcagaggc60actccttaggccctaaaacattgccactgggtctcagcccagttagtcctctgcagtttc120<210>406<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>406ttcttcactcccaaccccagtatcttcaaacagctcacaccctgctgtgctcagatcaat60actcagttgtctaagttgcctcgagactaaaggcaacagtgctgaaacatctcctggact120<210>407<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>407actcaccttgaagttctcaggatccacatgcagcttgtcacagtgcagttcactcagctg60ggcaaaggtgcccttgagatcatccaggtgctttatggcatctcccaaggaagtcagcac120<210>408<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>408caccttcttgccatgtgccttgactttggggttgcccatgatggcagaggcagaggacag60gttgccaaagctgtcaaagaacctctgggtccatgggtagacaaccaggagcctgtgaga120<210>409<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>409agattgacaagaacagtttgacagtcagaaggtgccacaaatcctgagaagcgacctgga60cttttgccaggcacagggtccttccttccctcccttgtcctggtcaccagagcctacctt120<210>410<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>410cttcccagggtttctcctccagcatcttccacattcaccttgccccacaggcttgtgata60gtagccttgtcctcctctgtgaaatgacccatggcgtctggactaggagcttattgataa120<210>411<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>411taacctcagacgttccagaagcgagtgtgtggaactgctgaagggtgcttccttttattc60ttcatccctagccagccgccggcccctggcctcactggatactctaagactattggtcaa120<210>412<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>412caagtttgccttgtcaaggctattggtcaaggcaaggctggccaacccatgggtggagtt60tagccagggaccgtttcagacagatatttgcattgagatagtgtggggaaggggccccca120<210>413<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>413ccaagaggatactgctgcttaattttttttatagcctttgccttgttccgattcagtcat60tccaatttttctctaatttattcttccctttagctagttttcttctcccaccatagaaga120<210>414<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>414agataccaggacttcttttgtcagccgtttttcaccttcttgtctgtagctccagtgagg60cctgtagtttaaagttaaagcatgtaccaatttttgaaaagttcagggattgtgaaatgt120<210>415<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>415tgtgttttaggcataggtccaggatttttgatgggacacgtcttagtctcatttagtaag60cattggtttccaaataagaagtgctatacttatctttgaatatactctctgtggttttag120<210>416<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>416taggccattatctcttaagttctcattagtgtagtgaaaaatcctataaagcaacagttt60cagtgcaggaatagattaatgttatgtaatataatataagactgaatccttacttcaata120<210>417<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>417atatctacttatccgtacctatttgaaataaatcacgcctgtttcatctcagcaaaagta60ttttttttatattcaggtatgtatgtaggcacccgatgatgtgtatttatcactggataa120<210>418<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>418taagtgtatgtgctggctgatgacccagggttttggtgtagctcttctatgctcggtaaa60gatgatggtagaatgctctttaccagatactatggattagaattaattatcttgtataaa120<210>419<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>419aaatgctaggttcacttcttagggaatcttattctaagacataagacatgtatttgcatg60gaaaacaactcttaagaggcagggactgttttattgactaatagtccacacactgtgaca120<210>420<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>420acagctgggatgtcactgtagtttagacatctttatctgtaactcagtgctgtttctgac60atattggccacttaacatggcaggaagtattcatgctgtttttttctttattttttcttt120<210>421<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>421ttggttttgcttttgttttttctctgaactcgatccatgaccttggtagattatgacgtc60agaaactctggaaatctggcttattggaggagagctctaccttcccctaacctatcaggt120<210>422<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>422aaactctggaaatctggcttattggaggagagctctaccttcccctaacctatcaggttg60ataggaattataataatattggtggaatcctttcagacttcataatcctgtgtaaggctt120<210>423<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>423aggaattataataatattggtggaatcctttcagacttcataatcctgtgtaaggcttat60atctgctcaaagtgttaggcggctaaaagaccagaaagatacatgttgacctgcgcaac119<210>424<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>424aataaaagttgaataagaaaggaaagaaaaagatttgtcaacttatcagtatcttccagt60tactcacataataataagtgacttctctcaatctaaggatgggtgagaaagatttttatt120<210>425<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>425tattggtatgctggtacagattatagagactgaggtgaacccaaattagggtctctttaa60gataggggatctgtgagatgggtgtgtatagatctttggccatatctgagagtctggttg120<210>426<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>426gttgggttccatttgtagagcctgacctttaagaatgtgtcagagactggtgtctaagcc60cgctaaggcctaaacaagtgaatcttttgaatctctcttttttttttttgagacagagt119<210>427<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>427gtgagccaccactcccagcctctaaacaagtgaatcttaattgctcctcctcagactaag60gaatatctaggatccctcctgttttcaaacaacttccccatttatccaaaaaccaaggca120<210>428<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>428aaaccaaggcagtgttctaaaagtcatgtataaacccttatttcctcttatgcttttgag60gcaatatcttttaagagtttgttgatttctccttatccataactgtcttattcctcgatt120<210>429<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>429attcctcgatttttcctatatcattgcttctgacattgattaaatcctaactgataa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aggcatgttgagtagaagtttccgaaaacaac120<210>454<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>454aacttgatgaaaaaacaaacaaacaaacaaaaacggctttatacctacattcctagacaa60ccctgacctcaaactgttccaaggtttgtgcccacccaaaaaattcagatgagcttaggt120<210>455<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>455ggttcaattttattctatgagccctacattcaacattctacctacctacaccctcacccc60cttccccattttaccagtattattgggttccctctctccctgtttttctttaagcaattg120<210>456<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>456ttgtctaatttttgtaaatgtagaatgtgagtgctgcaagagttctcagcgggagtttaa60aatccccaacaaattcggaaacaagccttcacttggtcacaatactgatgggaaatttaa120<210>457<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>457taacatattttagaaaatgtgtcttatttttctttgagcaaatcttttattttttttgca60aaaatctctttctaaacctcaattatcatgacccacataaaataaggcatttctatttcc120<210>458<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>458tccttgaaatggactttcatctaccaaaagccaaatttcattcttctttcacaagtctac60aattctataatacaattctctgggataaacacatcaagttctggcaagatttcctgaaaa120<210>459<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>459aaagttaagccaattcaggctgttagtagtcctttactgtcactagttctgaatcatgta60agttttggttatgctcactagaagtctgctgttctaacatcaagctcgacccatgatttc120<210>460<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>460ttctgagatctttgttggtctttccaataagattatgagcttcaattaatgtcaaaatat60aaagccaaaaaatcacatcaccagcacctgaactcaccttgaagttctcaggatccacat120<210>461<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>461catgcagcttgtcacagtgcagctcactcagcttagcaaaggcgggcttgaggttgtcca60tgtttttaatagcatctccaaaggaagtcagcaccttcttgccatgggccttgaccttgg120<210>462<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>462tggggttgcccaggatggcagagggagacgacaggtttccaaagctgtcaaaaaatctct60gggtccaggggtaaacaacgaggagtctatgaaatgacaccatatcagatacaaaattag120<210>463<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>463tagagatgcaaaaaatcttgaggactttcccaatcaacttgctagggtaatattcaccct60tcattcccatgcattgagaaccaatgcttacctgcccaaggcttcacctccagcctcttc120<210>464<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>464ttccacattcatcttgctccacaggctagtgacggcagccttctcctcagcagtaaaatg60caccatgatgccaggcctgagagcttgctagtgattgcagctgtgtcggaagcagatatg120<210>465<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>465atgtgctgctgcctctctgtctggccttttattctttactgccgaagttctggccccctg60ttctccatggtacttaaaagtcattggtcaaggctgacctgtgtccctcaggggtggagt120<210>466<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>466agtcaggtccggagagggtcagcagtgatggatggacactaagtttgtgataatgtgtgc60tggatcctgaggctcttttttgttggctcctcatctatctgcaacacaaatttccatttg120<210>467<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>467ttgtccccttttttaccctcttcatcatcttccaaaatgatatccatctctcccattctc60cttttccaagaaagcctcatataaaggagcaaatctcaaaataggaaaaaaagtttcagc120<210>468<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>468agccaaagcgcatttaacatttgccttaaaggtggtgacagtgacaaaaacagggccaag60gaaaagaaaataaagctgttaaaacagaatctcacccagttctagctctcttaaggagtg120<210>469<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>469gtgcattgtaaacaaaacttctgtaccttagtttctctagggagacaaaaaccgtacata60gttccttctagaaactgaacagaatagcaagtagtccacagtgggactaaagccttaatc120<210>470<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>470atcccaaagtacagtaccttggggtgattccctagagaggacagacagaaaagattacat60ccagtgcttccagagaatcctctctcttttcatttctctatgaccacaggggacattggc120<210>471<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>471ggctactttgtgagtattgcctggggctctcttcttgcttgcctgtctgtcctgcttata60cttctcactgggaagggagctgagaagcctaaaatcctaaaattatttaaagccagaatt120<210>472<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>472atttgtcatcaaacagagaaaaaagtgaatcgatatattaatcaggctaggagtcagggt60atattattcctctagtgtccttttttttttctgtatgtccccattttgatgacttgctag120<210>473<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>473tagctctttacttggtagagctgaaactggaagttgggatttacagtgtattcaattcga60tccatgtgcctgaagaatattgctcatgctatatcacttaatctgcccttataataccat120<210>474<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>474cattgtcattatcctcatattttagaatcaaggaataaattcacagaaattatttaacta60tcaatgtgacagaagtaatgattgggggaataatagaagcagagttccacaaattccagc120<210>475<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>475agcattgttaattctataaaagtcccttacatcaccataatctcattgccccagcccagt60tcctccttctggcttgttctacatccatttattttttcttttttctttttcttttctttc120<210>476<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>476atctgcccacctctgcctccgtctccatccatttctaccatttctttctcctatggctcc60ccttgccccaccagatctaggaatttctgttcctacaatttcctgtatgttcaggcccta120<210>477<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>477caatttcctgtatgttcaggccctagaggttcttcgtctttttcacttagcagtatggct60cctgtctcccaagtcaagtgcctttggggattccatattccaagtttactaagagcgttt120<210>478<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>478tattccaagtttactaagagcgtttctctcttctataacctgactttgttatttattata60ttttcttatgtttgtgataaaaaaaaaaaaaaaaaaaaacacttgtggcaagtaagaatg120<210>479<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>479aaaacacttgtggcaagtaagaatgtctcccttgcttttctcccatgattccagaagtct60tcacctgacttaatgactgcccaaattgttattattccaggccactgaatttctactcca120<210>480<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>480tccaggccactgaatttctactccattttcttttagctattaaccaatggtatctttctg60agcatatattctaaccattggctaacacagacaaaaccaggaattcctaaacttttttt119<210>481<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>481ccccagattaagacttcctgggacaaaatatatagcctaggaagacaagatcctaggttt60ggaaagaacgtatttgatccactgaaataaaagaacaatgactagacaaaaagcagctca120<210>482<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>482gctgcttgtagcttgaaccaagctgagcttggctactcagagaagaacagtcgttgagat60aatataattttttttaaccaattaagatacagctctgggttttcagggggaatttgctac120<210>483<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>483agatccacagtatgaaggcagtggcccttcctcagaacttgaatgtgagggtcagacatt60gccaaagtccaaggaataaggaccaggtatctcaaggccaagagtttggagaacaggttt120<210>484<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>484ctccctaaaacaagccctatgggtaatcccatcattcttcccattcagagtatggacacc60agtcttctcttagattcagagtatggggttgatcctctcctgctccctcggagccagttg120<210>485<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>485cagagcccacattttcttctctccttactgcctatggttccagacctggcttgcatccag60ggatctgacccattccatgtttccttatggctaaaggtggtagggaggagcttcaagaaa120<210>486<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>486ggttatagcattgaaaggcccaggtttgtgtctcagtaacaaggcttataaatcctgact60cagaagtcaggtaggctgcgggcagtctcattattgcttcgatgcttgttggttcaagat120<210>487<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>487aaattgcttcacctgctcatttttaagcattttatttgtttatcatatgagataccatga60aaaatggattattgcttttctttcctatattaaaagcccaaagttcagagagataagtgt120<210>488<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>488tatggccatccaggatagatcagaaagattagacagtcagaaaaagtaatcagtaagaat60attcatttattgtctatataattaaaattagtaaaataaaatctatgtatgtcttaagac120<210>489<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>489atttaagtataaaggacttttagaaagaaacacccaaattcgatgaagattaattcctgc60ctgtttgggtttgctttagcatttgtaatttcttaagttctatgcaggattctaaaaact120<210>490<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>490gtaagatgcctaatttaaacaaggaaacatccaatattttcttaaatctttctggctaat60ttatgacatatgtttaacctgaagagtcaaatattgtactgttcttagatgctattagta120<210>491<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>491tgaaaaattatataaattagattcttgttaagtaaagtaggcccttcacttcactgaatg60tttttcatggtattatctaagaaataaatactttaatgaatattctttaccacaaataac120<210>492<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>492ttactttatttttatttttaaaataggaaaaatataaacaaggcttgtaaaccactgata60ggaaaagagctgcttaggattctaaattagccagattttaaattattctgcttccattat120<210>493<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>493gtatctaaatctatattctcagaacaaaaatagatgtaagcaaatgattctactagattt60tgtgttagattttgcattatccaggaatgacttggatatcacaagtcataaattctgtgg120<210>494<211>114<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>494ctgccttgcaggaagcctgtggctattttctagtgtaattgtaaagaatgagagaataga60ccataacaagtgttcaaactgttgctttcttgttttcaacttttattttaagtt114<210>495<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>495ttctcatcatttagcttctaactgttgctttcgtagtgtacctctgcctcatctctcacg60aagtttgcaggtgagtttgagccagggctgaggctcattctcaagagtaatctctctctc120<210>496<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>496tctctctctggcaacttggagcacagacatcctattgtgtgactgacctcgggagccact60gtgcctaaagtacaaccagagttacttgtgaatgttaattaagcaggagggatctttaat120<210>497<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>497tctttaatgggaaaaaggagtagaaagccagaatcagccagttatgccacactttcctac60atgatgggcactgaaggttaaaacttgagtctgtcaacttagaaaactcataaatatccc120<210>498<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>498aatatcccattttccgctgaaatatagctttactttcctggtttctttgaccttttggga60ccttgagtaagtaaagatgccttcatttattttcatgattaaaattctaagaaattcttg120<210>499<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>499aattcttgggtttttttaattaaattgcattgcctaatgtatttatgaactaagaacata60gaaataaaacaatactctgaagtagttcagaatgtgctttcaatttatataaagagttaa120<210>500<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>500agagttaattcaaatgagactattttaagtgcagggctttgaatcttatgtctagaaatt60ttgaaaaacctctgattatatgctaagattccacctctagtgctagaactgagaagtcct120<210>501<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>501gaagtccttgacttggtgatcttttttaaattctgaaacaacagcaacataaagctaagg60actttttcttgcctatgcatgctatcttcagtactttgattatttagtattgaaactata120<210>502<211>120<212>DNA<213>人工序列<22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列<220><221>modified_base<222>(1)<223>生物素修飾<400>647gtattcatctgacagcataggaaggagagaaatccctctgtctcatttataccacatatt60gtgtttctatggccgaatcagcttaggttctacattgtgtggttttggataaattac117<210>648<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>648aatgtgaacctcttaagacactagcaacttgaatacataattgattttttattctgttac60aattatatactgaactcatgtgaggatccagtttctatatctaggcttttcaaactacct120<210>649<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>649agcaccagaagatgctcagctcaactggtagaggcttacgcctgtgaccccagcgctgag60aggccaggaactccagaccagcctgggcaaaacagaaattaaaaatgctcaacattatta120<210>650<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>650caccagaagatgctcagctcaactggtagaggcttacgcctgtgaccccagcgctgagag60gccaggaactccagaccagcctgggcaaaacagaaattaaaaatgctcaacattattagg120<210>651<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>651tgaagttgttttttaaaaaatcaccccacctaccctatcccaggcttccccaggaggtaa60ctaaaggtaatgagcttctttggctgcttccagaactttcccaagcacatcaaatgcatc120<210>652<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>652acatcaaatgcatcagaacctaaccacttgactgagggatgagcattttcactgttgcaa60gtaaccctcttgcaccaacactgacactaatgtgtattttgcagaacaaatttgtggatt120<210>653<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>653caaatttgtggattggcctcaccagggtgaagggtacgtgcatttgaaatggctcaacag60taccaacaggtgcgttttcttgcacagggctgcataacattttttttttttttttgagac120<210>654<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>654gtgagccaccgtgcccggcctgcataacatttttttttttcctgaaattcccagaaagga60aaatggtgtcttgttctatgttgcatttctttgattgagagggagagctgcatcacttaa120<210>655<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>655ctgcatcacttaattatttgcagagaattgcttttcttgttttctttacaggtggtctgt60tcttggatggtctggctgtgttctttctgaggaatacataacctctgctacacattttgc120<210>656<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>656ctacacattttgcaaggctttatccccgttgtccatgttttgattttatgtataatcaaa60aggtttgtgagttctcccgcacttcccaggagtgcctctgggatggaaatgagactgcag120<210>657<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>657aatgagactgcaggagcagggcttgaggctggaggggtgagatgggacagatgggggtgg60gggaacccagggcagtggccggtggtggtaatggaggcctcctcacagggaccctcacag120<210>658<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>658gggaccctcacagcgaccatgcgaatggagcaggactgtgactcaggtctcgctcttctg60acctaatcgtgctgctgccccaatgggcagaaccttggggctccagactggacatctctg120<210>659<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>659ctggacatctctgggctcaaaggatcccactgttcccccggttaccctctcagggttggc60ctcctgccagtaaccctggcactcattgttcattcttctgactatcgtcagtcataatga120<210>660<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>660tcagtcataatgagagctcgaactggtgaaagtgcagggagctcaccatgaccccagccc60acagaggtcctgggtgcgtccctgccctcgaagcagcactctggatcccagcgccaccct120<210>661<211>117<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>661ccagcgccaccctcatgtccatgtttgcacctcattggctgtgacagaaatgagacatca60ttgtcacacgctggcctgagggtcagtgggccttgctttggacctcagtttccccac117<210>662<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>662gagtcccagctctaagttctcccagggtctcctggacaatgaagcaccagggccaacctc60catttgctacaggggacatcctcaggctcttctctgctaagaccccacacctccaagtct120<210>663<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>663gtctcctcattttacctttaaatagctgtttcatgacctgcttttttgacggtaagtaga60tttttggaaactgaaacccctgacccttcctcccagcctgggcctgcccttggcaggata120<210>664<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>664gataggaggccttatcggtcctgccacttggtctgggcctcaaagggccaccgccatctg60caggagggccgggtggggttcacagacgctatctgggacttgcctggacacctccacctt120<210>665<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>665ccttctcagctgagtgttgctgccccaccagggagaaccactcacacacagtagtaatag60aaataatttaaaattcatgctgcaagttcctgagcgccctcccaacactgaggtggggg119<210>666<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>666attagcctgttcagggtcaccgagggtccactctcatgggagagtttgcagatgcccaat60ccggcattctgctgagtgtccagtggcttgtaagtggccagacaccctttgagctcagcc120<210>667<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>667ttgagctcagcctcagctgctcaggcacagaacgtgcctggagcttggaattcaggccag60aaaccaccagtggacaccagcattccacactcactgcacaggctggggctcaaaccaagg120<210>668<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>668ctcaaaccaaggcccagggacaggaagggacaagccccagccccagccggactcccagcc60cacacaaaccatcagggcttgtttcctgctccatggaagcctcagacatgtttcataacc120<210>669<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>669agtgctcaacagatgccagccaaacagacatggactcccctcaacacagtcaacccaagg60ttgactgtcaccaaacgcaaaagaccacactgtaaagcttttagaaatgtggtctagtgg120<210>670<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>670caaacagacatggactcccctcaacacagtcaacccaaggttgactgtcaccaaacgcaa60aagaccacactgtaaagcttttagaaatgtggtctagtggccgggcactgtggctcatgc120<210>671<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物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cggcttgtggggcacaggttgtgagaggtgcccgggacggcttgtgggacacaggttgtg120<210>720<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>720ttgtgagaggtgcctgggacggcttgtggggcacaggctgtgagggtgcctgggacggct60tgtggggcacaggttgtgagaggtgcccgggtcggcttgtggggcacaggttgtgagagg120<210>721<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>721agaggtgcccgggacggcttgtggggcacaggttgtgagacgtgcccgggacggcttgtg60gggcacaggctgtgagggtgcccgggtcggcttgtggggcacaggctgcaagaggtgccc120<210>722<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>722tgcccgggacggcttgtggggcacaggctgtgagggtgcccgggacggcttgtggggcac60aggctgtgagggtgcccgggacagctcgtggggcacaggttgtgagaggtgcccgggacg120<210>723<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>723ggacggcttgtggggcacaggctgtgagggtgcctgggacggcttgtggggcacaggttg60tgagaggtgcccgggacggcttgtggggcacaggttgtgaggatgcccgggatggcttgt120<210>724<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>724cttgtggggcacaggttgtgagaggtgcctgggacggcttgtggggcacaggctgtgagg60gtgcccgggacggcttgtggggcacaggctgtgagaggtgcctgggacggcttgtggggc120<210>725<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>725ggggcacaggctgtgaggatgcccgggacggcttgtggggcacaggttgtgaggggtgcc60caggacggcttgtggggcacaggctgcaagaggtgcccaggacggcttgtggggcacagg120<210>726<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>726acaggttgtgagaggtgcccgggacggcttgtggggcacaggctgtgagggagcccggca60cggcttgcagctacagggagaaaagacttggtgctgtgggcctgccttggggctggtggt120<210>727<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>727gtggtacagcccttatctgctgccctcaggatctcccggcccctctcgtccaggcccctg60caaccccatgccccagcctctgaggaccaaaggcgcccctgcttgggaagagggggctca120<210>728<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>728gctcaggggagtcgcctgacccggttccaagccaggctgatttaccgttgctaacatcct60atcgcacgcatccctctgcctcatgcacccaaccccaaggcctggtacactgcaggcccc120<210>729<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>729gccccaaggtcctgtgcgtcctttcaataccctcctcacctgcctcacctgcccccccta60ccctgactctggctggagaccccctccagggagttttcaaaacaaagggtgtcagtctcc120<210>730<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>730tctcctgtgggattccctcacctctgcagcctgcggtctgaaagctgccccatggtgtgt60agtgctaaacttccaacttactccaggccagcggtgacagcccgagggcaggaagggcac120<210>731<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>731ggcacccacactgagcctcaaacagctaattttgcaactgtaagtccatataattgtctt60gaaaagtaatttgtttcaaaaagctaaaaaacgaatactcttgagtctccttctagtaat120<210>732<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>732gtaattccccttctagaggtctatcaccaggaaaagatccaaagcactgatattcttcat60ggagttgtttataatagaaaaaaactagagcttgttcacaaaggggagctctgcaggctg120<210>733<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>733ggctgaagatgttgcacctgtcagcggggatgggggcacgcttgctgacgcagcaacgga60aaagcatcagtgtgtgaagatgcattttctctctttctattattattatttttattttta120<210>734<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>734cagtgatgcgacctcatcacaaccacgagccaccatgtgcggccccatgagcaagccacc60acgcccagcctttttttcccttgttttaaaaaatcctctatttaaaaaagatgtgcatgg120<210>735<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>735accacgagccaccatgtgcggccccatgagcaagccaccacgcccagcctttttttccct60tgttttaaaaaatcctctatttaaaaaagatgtgcatgggccgggcacggtggttcacgc120<210>736<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>736gtagagctggaggagggtctcctccaggctgcgatgagaacatagtgagcagaattgcag60gcctgcatgacctcaccttctgtgaggagtccggcctcccaagacgctttcctgcctagg120<210>737<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>737ggtgcccggctcagagtgtcccctacaaggctactggaggagaaccccagaccgagcctc60attcaggtgagggggctgcacaccggaggtgggagaggtctgtcccttcccaccctgtga120<210>738<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>738ttgcaaactggagctcataaggtgggccagagaagtttcagtgaagtgaggaatggatcg60tccctctgccagggcccatgtgctctaggtcaccctgtcatcacagggacagggaggtca120<210>739<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>739aggtcaaggacagtcactcctgaggccagtccgggctgggctgaccacgtggactctcat60gcccagattggggccccaatctccctgaagctggggctccagctgtgactcaggggtggg120<210>740<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>740ggtgggcagaaggggagacagaagcgataggttcctcagcccccagtcccacctgagggc60ccctttgtcactggatctgataagaaacaccacccctgcagccccctcccctcacctgac120<210>741<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>741cctgaccaatggccacagcctggctgggcccagctccctgtatataaggggaccctgggg60gctgagcactaccaaggccagtcctgagcaggcccaactccagtgcagccgcccaccctg120<210>742<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>742accctgccgccatgtctctgaccaagacttaggggaccatcattgtgtccatgtgggcca60agatctccacgcaggccgacaccatcggcaccgagactctggagaggtgagtgtcagatg120<210>743<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>743cagatgggactgccagagggactgggtgggaggccaggtatgtgagtggggacagtgggg60agcgggcagtggggaggggaccgtggggaggggacagtgagtaggagacagtggggagag120<210>744<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>744ggagaggacagtggagaggggacagtgaggaggggaccatgggaaggggaccgtggagtg60gggacagtgaggaggggaccatagggaggggacagtggggaggggacagtgaggagggga120<210>745<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>745aggggaccgtggggaggggacagtgaggaggggaccgtggggaggagacagtgaggaggg60gaccgtagggaggggacagtgaggaggggaccgtggggaggggacagtgaggaggggacc120<210>746<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>746gggaccgtggggaggggacagtgaggaggggaccgtgggaaggagacagtgaggagggga60ccttggggaggggacagtgaggaggggaccatggggaggggacagtgaggaggggacaat120<210>747<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>747gacaatggagaggggacagtgaggaggggactgtggggagaggacagtgaggaggggacc60atggggagggcacagtggggaggggagagtgaggaagggacagtgaggaggggactgtgg120<210>748<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>748ctgtggggaggggacagtggagacagatagccttccctctcagtgaggagggcagggtaa60ggagggaacgattaggagttgcacaaccatctgggctcgctgagacctgggcaggcacag120<210>749<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>749gcacaggcccaggttctgacaagcagagggtgaaaggtttcgttctaggcctgaagggcc60ttacagggcagccagggcactacagcctctaaagtcccagcatctgggatcagggcactg120<210>750<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>750gcactgtcccagcttcaaattcccagcatctgatcccctgggaggggccagggagctttt60ccttccctggaacgctgctgggaggtcatgagcctgcagaaggggtggcgggcaacccag120<210>751<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>751acccagtctggggctgggagggaggtcctgtggccagaggagacggtggaggggctgggg60gcaccaggcgtgctggaggcggagggcgggagatttggggaccaggctgcacagaacccg120<210>752<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>752aacccgtcggaagcagggcgatcagccgggagctgcagaggcctggggggcctctagccc60agggcagcctgggaggggcagctgcctgggcacccgggccccgcgaggaggggctggggc120<210>753<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>753tggggcctgctgcggggtcgcagatgtgtcccggtgctcggagagggccgcagggcgcgt60gggccgtggcgggaggccgcgctgctgggagctcacggcccccgccccccgtcccaggct120<210>754<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>754caggctcttcctcagccacccgcagaccaagacctacttcccgcacttcgacctgcaccc60ggggtccgcgcagttgcgcgcgcacggctccaaggtggtggccgccgtgggcgacgcggt120<210>755<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>755cgcggtgaagagcatcgacgacatcggcggcgccctgtccaagctgagcgagctgcacgc60ctacatcctgcgcgtggacccggtcaacttcaaggtgcgcggggcgcggtgcgggcgggg120<210>756<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>756ccgcccccagctcctgtcccactgcctgctggtcaccctggccgcgcgcttccccgccga60cttcacggccgaggcccacgccgcctgggccaagttcctatcggtcgtatcctctgtcct120<210>757<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>757ctgaccgagaagtaccgctgagcgccgcctccgggacccccaggacaggctgcggcccct60cccctgcccttcaccctcccacagttcctgccctgactccaataaatggatgaggacgga120<210>758<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>758gagcgatctgggctctgtgttctcagtattggagggaaggaggggagaagctgagtgatg60ggtccgggggcttcgcaggaactcggtcgtccccactgtcgtcgcggcctggggttcact120<210>759<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>759cttggggggcgccttggggaggttctagcccctgagcaccggagctgcggcccgggtgga60gcggagcagtcccgggccggcccgcggcgtctcctggggtccttgagtcggacgggcgtt120<210>760<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>760tttgtgcgtctcccggcttcccatatcgcacaaagattgtcacttcactaagcgtattgg60aagcgtgtcggggctcagggaacttttccacaaagcctgacgtccgaatcccgggactct120<210>761<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>761ctggcagctacgggggtccctgaggccggtccctccccgactcctaagagagtagggggt60ttcctgcccggtgttctctctccggttcctcccatgtgctccctcctggcagagcagtaa120<210>762<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>762aactttacccgaggggagtaaacagatgcccctaaagtctgcagtaaaggtgcccacgcg60caacggcgtgggtcaatgccagaaaccctgggatcccggaggtcgaggcctccacacaga120<210>763<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>763gacgggaacccgggctggttacgttccccggcgcaggccgagggtccccgcgttcccgcc60gcgctcgggccgataaggacgggcggggtgcccggaggctctataaggaggccagggcgg120<210>764<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>764ggcgggcgcggcccccagagcacgtcaggcggcgccatgctcagcgcccaggagcgcgcc60caaatcgcgcaggtctgggacctgattgcgggccacgaggcgcaattcggggcggagctg120<210>765<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>765tgctgctcaggtcggtagaggcggggtctccgggagctcagggaggtggagatgagggtt60ttgggcgcgtgggccgccaacgccatccaaggtccttcgggtgcggatccccgggctctg120<210>766<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>766tgggcggtgtgggcgctagtgaagccccacgcagccgccctcctccccggtcactgacct60ggtcctgcaggctcttcacggtgtaccccagcaccaaggtctacttcccgcacctgagcg120<210>767<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>767cgcctgccaggacgcgacgcagctgctgagccacgggcagcgcatgctggcggctgtggg60cgcggcggtgcagcacgtggacaacctgcgcgccgcgctgagcccgctggcggacctgca120<210>768<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>768cacgcgctcgtgctgcgcgtggacccagccaactttccggtgaggcctttccggccgggg60caatggtgcagcgcgcagccggggtgggggggctctgggggtccctagcggggcagaccc120<210>769<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>769cccgtctcaccggccccttctcctgcagctgctaatccagtgtttccacgtcgtgctggc60ctcccacctgcaggacgagttcaccgtgcaaatgcaagcggcgtgggacaagttcctgac120<210>770<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>770actggtgtggccgtggtgctgaccgaaaaataccgctgagccctgtgctgcgcaggcctt60ggtctgtgcctgtcaataaacagaggcccgaaccatctgcccctgcctgtgtggtctttg120<210>771<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>771tggggagctagcaaagcgaggtcactattgttggccagtgaagctcagggacctaaaagg60agcctcctagaactctcaaatgcgccccacccccggaggtttgtcctcccatggcgagga120<210>772<211>112<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>772gagtgcgatggggcagagggagcactgtgatgtggcgggggtagggagggtggccttcga60cttcaacccttgaatcgggcttccaaccatactgttcgcaaagcacttcccc112<210>773<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>773cagaaactgaggtcccagagccaaatgtgcaacctaattcgttggcccagagcagagggc60tccgcagacctgttcctttccccttccttcccccatggacacttcctcagtggcaaacct120<210>774<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>774tcagtggcaaacctgcgctagcctggttagccctccctgtgaccctgcagccctggggat60gaggtcgggaggaagtcctcagtggccacaatttggcagacagagcaggtttagtcttcc120<210>775<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>775aggtttagtcttccagcctgctcaatgacaagctgtgcgaccctgggcgtgtcccagagc60tctcaggcctttacctatcgaatagaaaaacaacgtccaactcacgagatttttgaaata120<210>776<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>776agatttttgaaataatttttgaaatcataacacagggtgggtgcctgcagggtcgttgcc60accccacccctccacccagccccagctgccgtgtctcaatctctgcaggtgcccaggcca120<210>777<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>777aggtgcccaggccaaggcactcccttccccaggttccctcttctccctccccaggactgg60gaagggaatcttagggctccaccccaggcttttcagacaaagaataggggctgaggaaag120<210>778<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>778ggggctgaggaaagagtgggaccttggaggtctccaaaccctgaatagggttggctctgg60gttggccatcctgggtctgtgtggggagcactggaccaggcctggcacccaggtctgacc120<210>779<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>779acccaggtctgacctggcagtcagcaacgaggtctgaagagagctgctggaagtggagcc60ctgactgtgagtcggccaaactccccccagcagtcagtgccagtgacctgttgccctgca120<210>780<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>780cctgttgccctgcactgcctgggaccccagcccggtagtttggagaacttggccccacgt60tatctacatcccccaactgtttttttgtttttgggggttttttttttttttgctttgttt120<210>781<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>781gtgagccaccacacccagcccccgcaactgtttacatggataattaacagctttttgtcc60caggcagagtttggtgtgaaagcagcttatgtttcactttggaaaaactgtgctcttctc120<210>782<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>782cttctccccatccaggaagctgcctgggtctgggccatatgtggataccttatgggtata60agctgctcaggaccctgtgtggaagctcaggacaatgccagcgggaaggctaccatgtgg120<210>783<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>783atgtggagagctggtctctgtttgggcaggactaagagacgcagggcagccttgggcaac60ctgtctactctcactcactcctcctcccctttcctgtgccaggcacctcctggcaacttg120<210>784<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>784aacttgccagccaatgaccctgcatcccaggcataagagctcctactctcccccaccttt60cacttttgagcttacacagactcagaaataagctgccgtggtgctgtctcctgaggacaa120<210>785<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>785ggacaaggctaacaccaaggcggtctgggagaaagttggcaaccacactgctggctatgc60cacggaggccctggagaggcaagaaccctcctctccctgctcacaccttgggtccaacgc120<210>786<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>786caacgcccactccagggctccactggccacccctaactattcttaccctggacccagccc60ccagcccctcactctttgcttccccctgaagcatgttcctgaccttcctctcacttggcc120<210>787<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>787ttggccctgagttatggctcagcccagatcaagaaacaatgcaagtaggtggccgacacg60ctgaccaatgccgtggtccacttagatgacatgcccaatgatgtgtctgagctgaggaag120<210>788<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>788aggaagctgcatgtccacgagctgtgggtggacccaggcaacatcagggagagctttggg60ctgggaggaatctagggtgtgggggcagctggccttcctcataggacagaccctcccacg120<210>789<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>789cccacgcgttcagggaggtggagcacaggtggcagtagtatctgcatcccctgactctct60ctccacagttcctgggtaaatgcctgctggtgacctaggcctgccacacccttcccagtt120<210>790<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>790ccagtttacccatgtggtgcctccatggacaaattatttgcttttgtgagtgctgtgttg60acctaaaaacaccattaagctagagcattggtggtcatgccccctgcctgctgggcctcc120<210>791<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>791gcctcccaccaggccctcctcccctccctgccccagcacttcctgatctttgaatgaagt60ccgagtaggcagcagcctgtgtgtgcctgggttctctctgtcccggaatgtgccaacagt120<210>792<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>792aacagtggaggtgtttacctgtctcagaccaaggacctctctgcagctgcatggggctgg60ggagggagaactgcagggagtatgggaggggaagctgaggtgggcctgctcaagagaagg120<210>793<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>793agaaggtgctgaaccatcccctgtcctgagaggtgccaggcctgcaggcagtggctcaga60agctggggaggagagaggcatccagggttctactcagggagtcccagcatcgccaccctc120<210>794<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>794accctcctttgaaatctccctggttgaacccagttaacatacgctctccatcaaaacaaa60acgaaacaaaacaaactagcaaaataggctgtccccaatgcaagtgcaggtgccagaaca120<210>795<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>795agaacatttctctcattctcaccccttcctgccagagggtaggtggctggagtgagggtg60ctggccctactcacacttcctgtgtcatggtgaccctctgagagcagcccagtcagtggg120<210>796<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>796agtggggaaggaggaaggggctgggatgctcacagccggcagcccacacctggggagact60cttcagcagagcaccttgcggccttactcctgcacgtctcctgcagtttgtaaggtgcat120<210>797<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>797gtgcattcagaactcactgtgtgcccagccctgagctcccagctaattgccccacccagg60gcctctgggacctcctggtgcttctgcttcctgtgctgccagcaacttctggaaacgtcc120<210>798<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>798acgtccctgtccccggtgctgaagtcctggaatccatgctgggaagttgcacagcccatc60tggctctcagccagcctaggaacacgagcagcacttccagcccagcccctgccccacagc120<210>799<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>799cacagcaagcctccccctccacactcacagtactgaattgagctttgggtagggtggaga60ggaccctgtcaccgcttttcttctggacatggacctctctgaattgttggggagttccct120<210>800<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>800ttccctccccctctccaccacccactcttcctgtgcctcacagcccagagcattgttatt60tcaacagaaacactttaaaaaataaactaaaatccgacaggcacggtggctcacacctg119<210>801<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>801aaataaataaataaactaaaatctatccatgctttcacacacacacacacacacacacac60acacacccttttttgtgttacttaaagtaggagagtgtctctctttcctgtctcctcaca120<210>802<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>802ttcctgtctcctcacacccacccccagaagagaccaaaatgaagggtttggaactcagcc60catgggccccatcccatgctgagggaacacagctacatctacaactactgccacaggctc120<210>803<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>803ctactgccacaggctctctttttggacaaaaataccatcatactgtagatacctgtgtac60aacttcctattctcagtgaagtgtctcccctgcatccctttcagccagttcattcagctc120<210>804<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>804ccagttcattcagctctgcgccattccacagtctcactgattattactatgtttccatca60tgatccccccaaaaaatcatgactttatttttttatttttattattattattttttttt119<210>805<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>805gtgagccaccgagcctggccaaaccatcacttttcatgagcagggatgcacccactggca60ctcctgcacctcccaccctccccctcgccaagtccaccccttccttcctcaccccacatc120<210>806<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>806cccctcacctacattctgcaaccacaggggccttctctcccctgtcctttccctacccag60agccaagtttgtttatctgtttacaaccagtatttacctagcaagtcttccatcagatag120<210>807<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>807gcatttggagagctgggggtgtcacagtgaaccacgacctctaggccagtgggagagtca60gtcacacaaactgtgagtccatgacttggggcttagccagcacccaccaccccacgcgcc120<210>808<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>808caccccacaaccccgggtagaggagtctgaatctggagccgcccccagcccagccccgtg60ctttttgcgtcctggtgtttgttccttcccggtgcctgtcactcaagcacactagtgact120<210>809<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>809tatcgccagagggaaagggagctgcaggaagcgaggctggagagcaggaggggctctgcg60cagaaattcttttgagttcctatgggccagggcgtccgggtgcgcgcattcctctccgcc120<210>810<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>810cccaggattgggcgaagccctccggctcgcactcgctcgcccgtgtgttccccgatcccg60ctggagtcgatgcgcgtccagcgcgtgccaggccggggcgggggtgcgggctgactttct120<210>811<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>811tccctcgctagggacgctccggcgcccgaaaggaaagggtggcgctgcgctccggggtgc60acgagccgacagcgcccgaccccaacgggccggccccgccagcgccgctaccgccctgcc120<210>812<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>812ccccgggcgagcgggatgggcgggagtggagtggcgggtggagggtggagacgtcctggc60ccccgccccgcgtgcacccccaggggaggccgagcccgccgcccggccccgcgcaggccc120<210>813<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>813ccgcccgggactcccctgcggtccaggccgcgccccgggctccgcgccagccaatgagcg60ccgcccggccgggcgtgcccccgcgccccaagcataaaccctggcgcgctcgcgggccgg120<210>814<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>814gcactcttctggtccccacagactcagagagaacccaccatggtgctgtctcctgccgac60aagaccaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcg120<210>815<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>815ggaggccctggagaggtgaggctccctcccctgctccgacccgggctcctcgcccgcccg60gacccacaggccaccctcaaccgtcctggccccggacccaaaccccacccctcactctgc120<210>816<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<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tcgctcgcccgtgtgttccccgatcccgctggagt60cgatgcgcgtccagcgcgtgccaggccggggcgggggtgcgggctgactttctccctcgc120<210>841<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>841gctagggacgctccggcgcccgaaaggaaagggtggcgctgcgctccggggtgcacgagc60cgacagcgcccgaccccaacgggccggccccgccagcgccgctaccgccctgcccccggg120<210>842<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>842ggcgagcgggatgggcgggagtggagtggcgggtggagggtggagacgtcctggcccccg60ccccgcgtgcacccccaggggaggccgagcccgccgcccggccccgcgcaggccccgccc120<210>843<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>843ccgggactcccctgcggtccaggccgcgccccgggctccgcgccagccaatgagcgccgc60ccggccgggcgtgcccccgcgccccaagcataaaccctggcgcgctcgcggcccggcact120<210>844<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>844ctcttctggtccccacagactcagagagaacccaccatggtgctgtctcctgccgacaag60accaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcggag120<210>845<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>845aggccctggagaggtgaggctccctcccctgctccgacccgggctcctcgcccgcccgga60cccacaggccaccctcaaccgtcctggccccggacccaaaccccacccctcactctgctt120<210>846<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>846ttctccccgcaggatgttcctgtccttccccaccaccaagacctacttcccgcacttcga60cctgagccacggctctgcccaggttaagggccacggcaagaaggtggccgacgcgctgac120<210>847<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>847accaacgccgtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctg60cacgcgcacaagcttcgggtggacccggtcaacttcaaggtgagcggcgggccgggagcg120<210>848<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>848cgatctgggtcgaggggcgagatggcgccttcctcgcagggcagaggatcacgcgggttg60cgggaggtgtagcgcaggcggcggctgcgggcctgggccctcggccccactgaccctctt120<210>849<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>849ttctctgcacagctcctaagccactgcctgctggtgaccctggccgcccacctccccgcc60gagttcacccctgcggtgcacgcctccctggacaagttcctggcttctgtgagcaccgtg120<210>850<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>850tgctgacctccaaataccgttaagctggagcctcggtggccatgcttcttgccccttggg60cctccccccagcccctcctccccttcctgcacccgtacccccgtggtctttgaataaagt120<210>851<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>851gtctgagtgggcggcagcctgtgtgtgcctgagttttttccctcagcaaacgtgccaggc60atgggcgtggacagcagctgggacacacatggctagaacctctctgcagctggatagggt120<210>852<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>852gtaggaaaaggcaggggcgggaggaggggatggaggagggaaagtggagccaccgcgaag60tccagctggaaaaacgctggaccctagagtgctttgaggatgcatttgctctttcccgag120<210>853<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>853agttttattcccagacttttcagattcaatgcaggtttgctgaaataatgaatttatcca60tctttacgtttctgggcactcttgtgccaagaactggctggctttctgcctgggacgtca120<210>854<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>854cactggtttcccagaggtcctcccacatatgggtggtgggtaggtcagagaagtcccact60ccagcatggctgcattgatcccccatcgttcccactagtctccgtaaaacctcccagata120<210>855<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>855tacaggcacagtctagatgaaatcaggggtgcggggtgcaactgcaggccccaggcaatt60caataggggctctactttcacccccaggtcaccccagaatgctcacacaccagacactga120<210>856<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>856gacgccctggggctgtcaagatcaggcgtttgtctctgggcccagctcagggcccagctc60agcacccactcagctcccctgaggctggggagcctgtcccattgcgactggagaggagag120<210>857<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>857agcggggccacagaggcctggctagaaggtcccttctccctggtgtgtgttttctctctg60ctgagcaggcttgcagtgcctggggtatcagagggagggttcccggagctggtagccata120<210>858<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>858taaagccctggccctcaactgataggaatatcttttattccctgagcccatgaatcaccc60ttggtaaacacctatggcaggccctctgcctgcgtttgtgatgtccttcccgcagcctgt120<210>859<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>859gtgggtacagtatcaactgtcaggaagacggtgtcttcgttatttcatcaggaagaatgg60aggtctgacctaaaggtagaaatatgtcaaatgtacagcagagggctggttggagtgcag120<210>860<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>860ttttatcaccttttttaaaacaaaaaagatataaggggtacagcagagtgagtgctgcat60atgcatttactattattcttgggttacatcccaggtactcaataaatgttcactgccctg120<210>861<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>861ctgccctgaagaaacacctgctacgagtcaggcacctcacagttgttatccgtttaattc60tcacaatctgagaagaaactgtcaccctcattttatataataaatgagaaaacagactcg120<210>862<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>862cagactcgggcaagtgtcacaatagaatcaagaggcagaataaactgacttccaatgcca60aatccatgccgaaattcagtgctataataatgtacatggccgggcgcggtggttcacgc119<210>863<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>863tttgtgtttttagtagagactaaataccatatagtgaacacctaagacggggggccttgg60atccagggcgattcagagggccccggtcggagctgtcggagattgagcgcgcgcggtccc120<210>864<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>864cggtcccgggatctccgacgaggccctggacccccgggcggcgaagctgcggcgcggcgc60cccctggaggccgcgggacccctggccggtccgcgcaggcgcagcggggtcgcagggcgc120<210>865<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>865agggcgcggcgggttccagcgcggggatggcgctgtccgcggaggaccgggcgctggtgc60gcgccctgtggaagaagctgggcagcaacgtcggcgtctacacgacagaggccctggaaa120<210>866<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>866ctggaaaggtgcggcaggctgggcgcccccgcccccaggggccctccctccccaagcccc60ccggacgcgcctcacccacgttcctctcgcaggaccttcctggctttccccgccacgaag120<210>867<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>867cacgaagacctacttctcccacctggacctgagccccggctcctcacaagtcagagccca60cggccagaaggtggcggacgcgctgagcctcgccgtggagcgcctggacgacctacccca120<210>868<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>868taccccacgcgctgtccgcgctgagccacctgcacgcgtgccagctgcgagtggacccgg60ccagcttccaggtgagcggctgccgtgctgggcccctgtccccgggagggccccggcggg120<210>869<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>869cggcggggtgggtgcggggggcgtgcggggcgggtgcaggcgagtgagccttgagcgctc60gccgcagctcctgggccactgcctgctggtaaccctcgcccggcactaccccggagactt120<210>870<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>870gagacttcagccccgcgctgcaggcgtcgctggacaagttcctgagccacgttatctcgg60cgctggtttccgagtaccgctgaactgtgggtgggtggccgcgggatccccaggcgacct120<210>871<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>871gcgaccttccccgtgtttgagtaaagcctctcccaggagcagccttcttgccgtgctctc60tcgaggtcaggacgcgagaggaaggcgccgcccctccccaaggaaaggcgagggcctggg120<210>872<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>872gcctggggcacacccccagtgcccagatccaggcgcgcctctttccacctccagcaggtt60tggggcctcggccatgggggcaccgaactgcgtgcagcctgaccctcccgaatggggtgg120<210>873<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>873ggggtggtaggtgagggccgcgggacgccccgggcggcgggctgcgaggacggccgactc60tgcccatcccgagggcggctggcttcgccctccccactctgcgccgagcacgcggcccgg120<210>874<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>874ggcccggacccaccgcgagaactccgcacctgcagcgtgaacgcacgcgggcggcgttaa60gggcccggggctgactcggagcaggttagggaacagcgccccctcccggcgcgagccggt120<210>875<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>875agccggtacctgcgcagcacccagccgccgcggctgtggcctggaatcggggacctgggg60tgccggggggttgtggtgaaggaggtgggaccagccccagcacctagccacgtagctggc120<210>876<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>876agctggcgaggtggaccaggaaccgacccagacccctgccgtcacccgacatcactacgg60agagtgaagcttttttatatttgtccacataaaaccaatcatggtcattgtagaacttcc120<210>877<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>877aacttccgaaaacaaggcttgctgcaccttcctgtgtatcccaggtccaggaatgggtgc60agcacatccttcagctgccgcttgacacgcggcaaactgtgtcatgtgtaaacaagaaca120<210>878<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>878aagaacaggacatggctgtcatatccaagagcacatgtgtaacacagacatgccacacac60acacacacacacacacggggtagaggcaggcctcatccacacccctaacatttgatgcgt120<210>879<211>113<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修飾<400>879gatgcgtagctgttccagtcttctaggcacatgtagagatgcttttcctcagaaatggta60ttctcaaggtgacactgaggaaaagtggacaggccgggcgcggtggctcacgc113當前第1頁1 2 3