Hz, 1Η), 6.31-6.35 (m, 1Η), 7.23 (s, 1Η), 7.48 (d, / = 8.4 Hz, 2Η), 7.59 (d, J =8.4 Hz, 2H)，8.40 (s，1H)，10.49 (s，1H); 13CNMR (100 MHz, CDCl3) δ 20.88， 20.92, 38.1, 64.0, 74.5, 82.7, 85.5, 100.3, 104.3, 124.4, 126.0, 127.2, 132. I, 138.4, 149.9, 156. 2, 161.4, 168.8, 170. 5, 170.9. HRMS (ESI) calcd for C22H2(lfcN3Na08 [M + Na] + : 556.0326，found: 556.0332。
[0017] 核苷 4e: mp 183-185 °C · 1H NMR (400 MHz, DMSO-4) δ 2.05 (s，3H)， 2.07 (s, 3H), 2.37-2.51 (m, 2H), 4.23-4.26 (m, 3H), 4.57 (d, / = 6. 4 Hz, 2H), 5.19-5.21 (m, 1H), 5.66 (t, / = 6.4 Hz, 1H), 6.17-6.20 (m, 1H), 6.76 (s, 1H), 8.25 (s, 1H), 11.81 (s, 1H) ; 13C NMR (100 MHz, DMS〇-i/6) δ 20.9, 21.1, 37.2, 55.2, 64.1, 74.5, 82.2, 85.8, 102.2, 103.6, 139.2, 150.1, 156.4, 161.4, 170.5, 170.7, 173.3. HRMS (ESI) CalcdforC17H19N3NaO9 [M + Na] + : 432.1014, found: 432. 1025.抗利什曼原蟲活性：IC5Q=3. 39±0. 76μΜ。
[0018] 核苷4f: mp 181-183 °C. 1H NMR (400 MHz, CDCl3) δ 2· 11 (s, 3H), 2· 19 (s, 3H), 2. 27-2. 32 (m, 1H), 2. 53-2. 57 (m, 1H), 4. 30-4. 40 (m, 3H), 4. 47 (s, 2H), 5.26-5.27 (m, 1H), 6.38-6.41 (m, 1H), 7.01 (s, 1H), 8.43 (s, 1H), 9.93 (s, 1H) ; 13C NMR (100 MHz, DMS〇-i/6) δ 20. 3, 20.9, 21. 2, 37. 2, 64. I, 74. 5, 82. 3, 85.8, 103.1, 104.6, 139.5, 150.0, 157.0, 161.4, 168.2, 170.5, 170.7. HRMS (ESI) calcd for C17H18BrN3NaO8 [Μ + Na] + : 494.0169，found: 494.0170。
[0019] 核苷 4g: mp 104-106 °C · 1H NMR (400 MHz, CDCl3) δ 〇· 89 (t，/ = 6.8 Hz, 3H), 1.28-1.29 (m, 10H), 1.68-1.75 (m, 2H), 2.14 (s, 3H), 2.22 (s, 3H), 2.31-2.39 (m, 1H), 2.54-2.59 (m, 1H), 2.75 (t, / = 7.6 Hz, 2H), 4.33-4.43 (m, 3H), 5. 30 (d, / = 6. 4 Hz, 1H), 6. 42-6. 46 (m, 1H), 6. 69 (s, 1H), 8. 42 (s, 1H), 10.37 (d, /=2.4 Hz, 1H); 13CNMR (100 MHz, CDCl3) δ 14.0，20.75，20.83， 22.5, 26.7, 27.4, 29.0, 29.1, 31.7, 38.0, 63.9, 74.4, 82.6, 85.3, 101.1, 105. I, 138. I, 150. 0, 155. 5, 161. 3, 170. 4, 170. 8, 174. 0 (one 13C signal was not observed). HRMS (ESI) calcd for C24H33N3NaO8 [M + Na] + : 514.2160, found: 514.2153. 抗利什曼原蟲活性：IC5Q=20. 91±8. 38μΜ。
[0020] 核苷 4h: mp 112-113 °C · 1H NMR (400 MHz, CDCl3) δ 2· 15 (s, 3H)， 2.43-2.56 (m, 2H), 4.08-4.11 (m, 1H), 4.24-4.37 (m, 3H), 6.20-6.23 (m, 1H), 7.23 (s, 1H), 7.37-7.42 (m, 3H), 7.74-7.76 (m, 2H), 8.38 (s, 1H), 10.47 (s, 1H) ; 13C NMR (100 MHz, CDCl3) δ 20.8，38.0，60. 2，63. 1，82. 2，85.9，99.9， 104.2, 125.8, 127.1, 128.9, 130.2, 138.8, 149.8, 156.2, 161.5, 170.0, 170.9. HRMS (ESI) calcd for C2tlH18N6NaO6 [Μ + Na] + : 461. 1180, found: 461. 1183。
[0021] 核苷 4i: mp 77-79 °C. 1H NMR (400 MHz, CDCl3) δ 2. 15 (s, 3H), 2. 45-2. 57 (m, 2H), 4.10-4.12 (m, 1H), 4.25-4.35 (m, 3H), 6.21 (t, / = 6.0 Hz, 1H), 7.09 (t, /= 8.4 Hz, 2H), 7.17 (s, 1H), 7.72-7.75 (m, 2H), 8.38 (s, 1H), 10.40 (s, 1H) ; 13C NMR (100 MHz, CDCl3) δ 20.8，38.0，60. 3，63. I, 82. 2，85.9，99. 7， 104.1, 116.1 (d, J= 22.1 Hz, 2C), 123.5 (d, / = 3.8 Hz, 1C), 127.9 (d, J = 8.4 Hz, 2C), 138.8, 149.7, 156.3, 161.4, 163.7 (d, / = 249. 2 Hz, 1C), 169.1, 170.9. HRMS (ESI) calcd for C20H17FN6NaO6 [M + Na] + : 479.1086，found: 479.1088.抗 利什曼原蟲活性：IC5tl > 12. 5μΜ。
[0022] 核苷 4j: mp 150-152 °C · 1H NMR (400 MHz, DMSO-4) S 2.04 (s，3Η)， 2.38-2.44 (m, 1H), 2.51-2.58 (m, 1H), 4.10 (m, 1H), 4.24, (s, 2H), 4.42-4.44 (m, 1H), 4. 57 (d, / = 4. 4 Hz, 2H), 5. 64 (m, 1H), 6. 10 (t, / = 6. 0 Hz, 1H), 6.75 (s, 1H), 8.21 (s, 1H), 11.78 (s, 1H) ; 13CNMR (100 MHz, DMS〇-i/6) δ 20.9, 37.2, 55.2, 60.4, 63.5, 81.9, 85.7, 102.2, 103.3, 139.5, 150.0, 156.4, 161.5, 170.7, 173.3. HRMS (ESI) calcd for C15H16N6NaO7 [M + Na] + : 415.0973, found: 415. 0966.抗利什曼原蟲活性：IC5tl >12. 5μΜ。
[0023] 核苷 4k: mp 190-192 °C. 1H NMR (400 MHz, CDCl3) δ 2· 07 (s, 3Η), 2· 10 (s, 3H), 2· 22 (s, 3H), 4· 32-4. 37 (m, 3H), 5· 39-5. 40 (m, 1H), 5· 46-5. 48 (m, 1H)， 6.19 (d, /=4.4 Hz, 1Η), 7.24 (s, 1Η), 7.38-7.40 (m, 3Η), 7.76 (d, /=6.8 Hz, 2Η)，8.41 (s，1Η)，10.28 (brs，1H); 13CNMR (100 MHz, CDCl3) δ 20.4，20.5， 20.8, 63.2, 70.5, 73.1, 80.5, 87.3, 99.9, 105.0, 125.8, 127.2, 128.9, 130.2, 138. 5, 149.9, 156. 1, 161. 2, 169. 7, 169.8, 170.0, 170.8. HRMS (ESI) calcd for C24H23N3NaO10 [Μ + Na] + : 536. 1276, found: 536. 1282〇
[0024] 核苷 41: mp 235-237 °C. 1H NMR (400 MHz, CDCl3) δ 2· 07 (s, 3Η), 2· 11 (s, 3Η), 2.23 (s, 3Η), 4.35-4.39 (m, 3Η), 5.39-5.41 (m, 1Η), 5.45-5.47 (m, 1Η), 6.19 (d, /= 5.6 Hz, 1Η), 7.10 (t, / = 8.8 Hz, 2Η), 7.19 (s, 1Η), 7.74-7.78 (m, 2Η), 8.41 (s, 1Η), 10.19 (s, 1H); 13CNMR (100 MHz, CDCl3) δ 20.4，20.5， 20.8, 63.2, 70.5, 73.1, 80.5, 87.3, 99.7, 104.9, 116.1 (d, /=22.1 Hz, 2C), 123.6 (d, J= 3.0 Hz, 1C), 127.9 (d, /=9.1 Hz, 2C), 138.5, 149.9, 156.1, 161.1, 163.7 (d, / = 249.9 Hz, 1C), 169.1, 169.71, 169.74, 170.8. HRMS (ESI) calcd for C24H22FN3NaOltl [Μ + Na] + : 554.1181, found: 554.1180.抗利什曼原蟲活性： IC5tl=O. 78 ±0. 08μΜ。
[0025] 核苷4m: mp >300 °C. 1H NMR (400 MHz, DMSO-4) S 1.85 (s, 3Η), 4· 15-4. 18 (m, 1H), 4.25-4.28 (m, 1H), 5.06 (s, 1Η), 6.12 (s, 1Η), 6.49 (d, / = 4.0 Ηζ, 1Η), 6.87 (s, 1Η), 7.32 (s, 1Η), 7.49-7.51 (m, 3Η), 7.86 (d, / = 6.0 Hz, 2Η), 8.08 (s, 1Η), 11.90 (s, 1Η) ; 13C NMR (100 MHz, DMS〇-i/6) δ 20.6, 64.6, 84.6, 90.3, 100.8, 103.3, 126.0, 126.8, 127.1, 129.7, 130.9, 134.8, 139.7, 150.5, 157.4, 161.5, 169.4, 170.7. HRMS (ESI) CalcdforC20H17N3NaO6 [Μ + Na] + : 418.1010, found: 418. 1023。
[0026] 核苷 4η: mp 136-138 °C · 1H NMR (400 MHz, CDCl3) δ 1.98_2· 04 (m, 4Η), 2· 09 (s, 3Η), 2· 80-2. 85 (m, 1Η), 4· 33-4. 34 (m, 1Η), 4· 45-4. 50 (m, 1Η)， 4. 54-4. 57 (m, 1Η), 5. 20 (d, / = 6. 0