（bardoxolonemethyl(O)DO))由于大量嚴(yán)重 的不利事件沒(méi)能完成III期。雖然兩種藥物都是Nrf-2的共價(jià)活化劑，它們的不同之處在 于Nrf-2可誘導(dǎo)基因的譜圖是不同的，所述Nrf-2可誘導(dǎo)基因被活化、在結(jié)構(gòu)上不同并且結(jié) 果可能具有不同的脫靶結(jié)合譜圖，從而導(dǎo)致不同的臨床結(jié)果。其他有前途的方法包括S0D 模擬物（如AE0L10113)、N0X抑制劑（如雷公藤紅素（celestrol))77和髓過(guò)氧物酶抑制劑 (如2-硫代黃嘌呤和ADZ5904)'
[0207] 結(jié)論
[0208] 在coro中發(fā)現(xiàn)了R0S和羰基化物的水平升高，并且這些可與炎癥增加、氣道重塑、 自身免疫性和皮質(zhì)類(lèi)固醇抗性相關(guān)。此外，全身性氧化應(yīng)激也可能在許多C0PD共病（如心 血管疾病和代謝綜合征）中是一個(gè)因果聯(lián)系。局部氧化應(yīng)激還可促進(jìn)肺癌的發(fā)展。在初始 暴露于R0S環(huán)境后，氧化應(yīng)激的隨后的細(xì)胞內(nèi)來(lái)源和長(zhǎng)期性對(duì)于理解這一疾病的病理生理 學(xué)是重要的。存在的抗氧化劑在coro研究中的失敗表明需要開(kāi)發(fā)靶向正確的細(xì)胞內(nèi)區(qū)室 的新的更強(qiáng)力的抗氧化劑。靶向不同細(xì)胞區(qū)室的抗氧化劑的組合可證實(shí)比單一治療更有 效。以類(lèi)似的方式，組合抗氧化劑與抗炎藥、支氣管舒張劑、抗生素和他汀類(lèi)可以補(bǔ)充或在 皮質(zhì)類(lèi)固醇的情況下提高/恢復(fù)它們的效力。
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